DMC1

  • Official Full Name

    DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)

  • Overview

    The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.

  • Synonyms

    DMC1;DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast);DMC1 (dosage suppressor of mck1, yeast homolog) meiosis specific homologous recombination;meiotic recombination protein DMC1/LIM15 homolog;LIM15;disrupted meiotic cDNA 1 homolog;dJ199H16.1;DMC 1;DMC1 dosage suppressor of mck1 homolog;DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast);DMC1 homologue;DMC1H;HsLim15;MGC150472;MGC150473;disrupted meiotic cDNA1, yeast, homolog of

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • Mammalian cells
  • HEK293T
  • GST
  • His
  • Non
  • Flag
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DMC1-12035H Recombinant Human DMC1, GST-tagged E.coli Human GST 1-165a.a.
DMC1-2703H Recombinant Human DMC1 Protein, GST-tagged Wheat Germ Human GST
DMC1-2919Z Recombinant Zebrafish DMC1 Mammalian Cell Zebrafish His
DMC1-6900HCL Recombinant Human DMC1 293 Cell Lysate HEK293 Human Non
DMC1-1309HFL Recombinant Full Length Human DMC1 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
Dmc1-2583M Recombinant Mouse Dmc1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DMC1-4107H Recombinant Human DMC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
DMC1-769H Recombinant Human DMC1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
DMC1-769H-B Recombinant Human DMC1 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    DMC1 involved in several pathways and played different roles in them. We selected most pathways DMC1 participated on our site, such as Cell Cycle,Meiosis,Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle THRSP,CCND2A,ESPL1,WRAP53,WEE1,ODF2B,CEP63,TEX12,CENPJ,PRKDC
    Meiotic recombination MND1,PSMC3IP,MSH5,MSH4,TEX15,SPO11
    Ovarian Infertility Genes INHA,ZP3,NRIP1,NR5A1,MSH5,ZP2,DAZL,SYNE2,GJA4
    Meiosis MSH5,PSMC3IP,TERF2IP,TEX12,MND1,STAG2,SYNE1,FKBP6,DIDO1,SUN1

    Protein Function

    DMC1 has several biochemical functions, for example, ATP binding,DNA binding,DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DMC1 itself. We selected most functions DMC1 had, and list some proteins which have the same functions with DMC1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding KIF20A,CHD8,MYHZ1.1,SCYL1,MAST4,Aatk,UBE2A,MYH6,UBE2D1,HSP104
    recombinase activity XRCC2,RAD51L1,XRCC3,RAD51C,RBPJ,RAD51L3,RAD51D,RAD51B,RAD51
    DNA binding FLI1B,RELA,BCL3,HMGB1B,NFYA,ZBTB5,RAD51AP1,ZFP553,SMAD5,RBM5
    protein binding CSF2RA,SNRPD3,ACTL6A,KRT33B,ABT1,RFX4,ODAM,VIL1,RAP1GDS1,EXOC3
    four-way junction DNA binding HMGB2,RAD51,HMGB1,YY1,RAD51L1,HMGB3,RAD51L3,MEN1
    single-stranded DNA binding MEIOB,XRCC2,MCM6,SSBP1,RPA2,SWSAP1,FUBP1,TSN,TTC6,XPC
    contributes_to endodeoxyribonuclease activity RAD51L1,RAD51L3,XRCC2,ERCC4,RAD51D,RAD51,RAD51B
    DNA-dependent ATPase activity TOP2A,ERCC6,ERCC2,CDK7,MSH4,DHX36,SMARCA4,MSH3,RAD51L1,XRCC2
    double-stranded DNA binding DDX58,LSM14A,AKAP8,RAD51,MTERF,FBXO18,MEN1,PNKP,FEV,XRCC5

    Interacting Protein

    DMC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMC1.

    BRCA2;79734;SDCBP;PSMA3

    Resources

    References

    • Dyce, PW; Shen, W; et al. Analysis of Oocyte-Like Cells Differentiated from Porcine Fetal Skin-Derived Stem Cells. STEM CELLS AND DEVELOPMENT 20:809-819(2011).
    • Johnson, R; Borde, V; et al. Excess single-stranded DNA inhibits meiotic double-strand break repair. PLOS GENETICS 3:2338-2349(2007).

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