DIS3
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Official Full Name
DIS3 mitotic control homolog (S. cerevisiae) -
Overview
Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells. -
Synonyms
DIS3;DIS3 mitotic control homolog (S. cerevisiae);KIAA1008;exosome complex exonuclease RRP44;dis3p;EXOSC11;exosome component 11;RRP44;Mitotic control protein dis3 homolog;Protein DIS3 homolog;Ribosomal RNA processing protein 44;Ribosomal RNA-processing protein 44;RRP44_HUMAN;2810028N01Rik;bA555G22.1;RP11-342J4.3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DIS3-12004H | Recombinant Human DIS3, His-tagged | E.coli | Human | His | 607-958a.a. | |
| DIS3-4602M | Recombinant Mouse DIS3 Protein | Mammalian Cell | Mouse | His |
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| DIS3-6919HCL | Recombinant Human DIS3 293 Cell Lysate | HEK293 | Human | Non |
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| DIS3-2383M | Recombinant Mouse DIS3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DIS3-2383M-B | Recombinant Mouse DIS3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dis3-2568M | Recombinant Mouse Dis3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DIS3-6219H | Recombinant Human DIS3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
DIS3 involved in several pathways and played different roles in them. We selected most pathways DIS3 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | LSM3,CNOT6,WDR61,LSM5,EXOSC8,PATL1,EXOSC1,CNOT8,PABPC1A,CNOT7 |
Protein Function
DIS3 has several biochemical functions, for example, 3-5-exoribonuclease activity,RNA binding,endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DIS3 itself. We selected most functions DIS3 had, and list some proteins which have the same functions with DIS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | ARFGEF1,RASGRP1,FAM116B,DOCK6,RALGDS,ITSN2A,RAPGEF4,RAPGEF3,DENND6A,RAPGEF1B |
| protein binding | ZBTB32,NAPB,STAC3,DHRS2,SLC6A4,CHTOP,USH2A,KRT86,EIF3G,FZD7 |
| RNA binding | DKC1,RNMTL1B,ILF3B,CNOT4B,CRNKL1,RBBP7,ALYREF,RNASEL2,HBP1,RDM1 |
| 3-5-exoribonuclease activity | DIS3L2,CNOT7,REXO2,EXOSC5,CNOT8,USB1,ISG20,EXOSC4,EXOSC7,TOE1 |
| endonuclease activity | CENPT,MRE11A,RNASEL4,G3BP1,DROSHA,RNASE2,RNASE6,RNASEL3,ENDOU2,RNASE4 |
Interacting Protein
DIS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIS3.
EXOSC10;EXOSC3;EXOSC8;EXOSC2;EXOSC4;NME2;BABAM1;ZBTB17;hemA;NTMT1;ssrna_ug
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