DGUOK
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Official Full Name
deoxyguanosine kinase -
Overview
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two;deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein;encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In;addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of;lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative;splice variants encoding different protein isoforms have been described for this gene. -
Synonyms
DGUOK;deoxyguanosine kinase;deoxyguanosine kinase, mitochondrial;dGK;Deoxyguanosine kinase mitochondrial;OTTHUMP00000160251;OTTHUMP00000160252;mitochondrial deoxyguanosine kinase;MTDPS3
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&SUMO
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
DGUOK involved in several pathways and played different roles in them. We selected most pathways DGUOK participated on our site, such as Metabolic pathways,Metabolism,Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGUOK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | APRT,NME1,AK7B,ADA,NME6,NME5,NTPCR,ENPP4,ADCY1A,POLR3GL |
| Metabolic pathways | CELL,CYP27A1,CYP4F2,AGMAT,ACSL3,ZNRD1,MTHFD1B,IMPA2,ENOPH1,HSD17B4 |
| Metabolism | CYP4F12,CTRB1,SLC26A2,FAAH2B,SLC16A8,CYGB,ARSF,ABHD14B,CYGB1,GLRX |
| Purine salvage | ADK,ADA,ADAL,PNP5B,TM9SF1,DCK |
| Metabolism of nucleotides | DCK,ADAL,ADA,AK8,PROZA,AK7A,TM9SF1,NUDT1,DHODH,DPYS |
Protein Function
DGUOK has several biochemical functions, for example, ATP binding,deoxyguanosine kinase activity,nucleoside kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGUOK itself. We selected most functions DGUOK had, and list some proteins which have the same functions with DGUOK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | XRCC2,SPG7,SPHK2,GLULC,SLC27A2,CLK3,DNAJA1,MAP2K6,MCCC2,ACSL1 |
| nucleoside kinase activity | UCK2,UCK1,UCK2A,UCK2B,TK1,DCK |
Interacting Protein
DGUOK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGUOK here. Most of them are supplied by our site. Hope this information will be useful for your research of DGUOK.
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References
- Zheng, YW; Wang, AW; et al. B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. BLOOD 123:931-934(2014).
- Sharma, S; Moon, CS; et al. Biomarkers in Parkinson's disease (recent update). NEUROCHEMISTRY INTERNATIONAL 63:201-229(2013).
