DEF6
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Official Full Name
differentially expressed in FDCP 6 homolog (mouse) -
Overview
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly;expressed in B and T cells (Gupta et al., 2003 (PubMed 12923183)). -
Synonyms
DEF6;differentially expressed in FDCP 6 homolog (mouse);differentially expressed in FDCP (mouse homolog) 6;differentially expressed in FDCP 6 homolog;IBP;SLAT;SWAP 70 like adaptor protein of T cells;SWAP70L;DEF-6;IRF4-binding protein;SWAP-70-lik
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DEF6-11923H | Recombinant Human DEF6, GST-tagged | E.coli | Human | GST | N-term-336a.a. | |
| DEF6-2516H | Recombinant Human DEF6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DEF6-4442M | Recombinant Mouse DEF6 Protein | Mammalian Cell | Mouse | His |
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| DEF6-460H | Recombinant Human DEF6 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| DEF6-491H | Recombinant Human DEF6 Protein, His-tagged | E.coli | Human | His |
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| DEF6-6993HCL | Recombinant Human DEF6 293 Cell Lysate | HEK293 | Human | Non |
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| DEF6-2284M | Recombinant Mouse DEF6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DEF6-2284M-B | Recombinant Mouse DEF6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DEF6-2421HF | Recombinant Full Length Human DEF6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 336 amino acids |
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| Def6-2517M | Recombinant Mouse Def6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DEF6-4588H | Recombinant Human DEF6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
DEF6 involved in several pathways and played different roles in them. We selected most pathways DEF6 participated on our site, such as Regulation of RAC1 activity,Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RhoA activity | DLC1,ARHGEF3,ARHGAP9,ECT2,MYO9B,OBSCN,NET1,ARHGEF28,ARHGEF10L,ABR |
| Regulation of RAC1 activity | RALBP1,ARHGAP17,CHN2,SPATA13,RAP1GDS1,EPS8,CHN1,ARHGAP9,ARHGAP1,DOCK6 |
Protein Function
DEF6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEF6 itself. We selected most functions DEF6 had, and list some proteins which have the same functions with DEF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PRKX,NUDT4,TTC1,FAM122A,RNF19B,HMGN2,GOSR2,ATXN7L3,HSCB,TMEM123 |
Interacting Protein
DEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEF6.
PTK2;PLSCR1;TCF4;CDC42EP1;HOMEZ;PBXIP1;EIF4ENIF1
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