DDAH1
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Official Full Name
Dimethylarginine Dimethylaminohydrolase 1 -
Overview
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. -
Synonyms
DDAH1;N(G),N(G)-dimethylarginine dimethylaminohydrolase 1;DDAHI;DDAH-1;dimethylargininase-1;NG, NG-dimethylarginine dimethylaminohydrolase;EC 3.5.3.18;OTTHUMP00000012304;FLJ2553;FLJ21264;dimethylarginine dimethylaminohydrolase 1
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- E. coli
- In Vitro Cell Free System
- HEK293T
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
- His&Myc
Involved Pathway
DDAH1 involved in several pathways and played different roles in them. We selected most pathways DDAH1 participated on our site, such as Metabolism,Metabolism of nitric oxide,eNOS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| eNOS activation and regulation | SPRB,NOSIP,DDAH2,GCHFR,LYPLA1,NOSTRIN,CYGB,CYGB1,ZDHHC21,CYGB2 |
| Metabolism | SULT1B1,LMF1,CIAO1,CYP8B2,CYB5R3,DCK,B3GNT2,PLB1,ACOT12,GGT6 |
| Metabolism of nitric oxide | NOSTRIN,LYPLA1,SPRB,CYGB,DDAH2,NOSIP,CYGB1,ZDHHC21,GCHFR,CYGB2 |
| eNOS activation | LYPLA1,CYGB1,CYGB,ZDHHC21,CYGB2,DDAH2 |
Protein Function
DDAH1 has several biochemical functions, for example, amino acid binding,catalytic activity,dimethylargininase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDAH1 itself. We selected most functions DDAH1 had, and list some proteins which have the same functions with DDAH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid binding | TPH2,KARS,TAT,DDC,GCHFR,TPH1A,TH,TPH1,AGXT,AARS2 |
| dimethylargininase activity | DDAH2 |
| catalytic activity | ISOC1,AZIN1B,FHIT,LDHBB,DBH,APOBEC2B,AZIN1A,TM9SF1,ALDOAA,LGI1A |
| metal ion binding | RNF121,ZMYND12,ATP8A1,ACAP1,PLA2G4F,C6AST4,MB,MOB4,PPM1NB,RTCB |
Interacting Protein
DDAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDAH1.
der;IQCB1
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References
- Ferrigno, A; Rizzo, V; et al. Changes in ADMA/DDAH Pathway after Hepatic Ischemia/Reperfusion Injury in Rats: The Role of Bile. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Yokoro, M; Suzuki, M; et al. Asymmetric Dimethylarginine, an Endogenous NOS Inhibitor, Is Actively Metabolized in Rat Erythrocytes. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76:1334-1342(2012).
