DCP1A
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Official Full Name
decapping mRNA 1A -
Overview
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] -
Synonyms
DCP1A;decapping mRNA 1A;SMIF;SMAD4IP1;HSA275986;Nbla00360;mRNA-decapping enzyme 1A;decapping enzyme hDcp1a;transcription factor SMIF;DCP1 decapping enzyme homolog A;putative protein product of Nbla00360;Smad4-interacting transcriptional co-activator
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DCP1A involved in several pathways and played different roles in them. We selected most pathways DCP1A participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | C1D,CNOT8,CNOT10,TOB2,RQCD1,HSPA9,LSM8,PFKMB,CNOT3A,PATL1 |
Protein Function
DCP1A has several biochemical functions, for example, enzyme activator activity,hydrolase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCP1A itself. We selected most functions DCP1A had, and list some proteins which have the same functions with DCP1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | FAHD2B,TMPRSS13B,CCC2,KLK1B16,RPE65B,CEL.1,ADAM1B,PTPRK,PLAUA,PNPLA7 |
| protein binding | PPP3R1,SKP2,SNRNP70,ATP6V1D,VMP1,MED20,HPCAL4,FBXO7,RCAN1,LAIR2 |
| enzyme activator activity | SAE1,DNMT3L,GMFG,PRKCD,PSAPL1,CTAGE5,RAB3GAP2,GM1679,CTSA,MMP15 |
| identical protein binding | CAV1,CTSC,CLDN17,APAF1,SSNA1,SNX8,EPS15,MBIP,SNX16,SERPINA1A |
Interacting Protein
DCP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DCP1A.
DCP2;UPF1
Resources
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References
- Menon, B; Sinden, J; et al. Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833:1173-1179(2013).
- Osugi, K; Suzuki, H; et al. Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins. JOURNAL OF BIOCHEMISTRY 151:657-666(2012).
