Cdh3
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Official Full Name
cadherin 3, type 1, P-cadherin (placental) -
Overview
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. -
Synonyms
CDH3;cadherin 3, type 1, P-cadherin (placental);CDHP;HJMD;PCAD
Recombinant Proteins
- Human
- Mouse
- Pig
- Mus musculus
- Mammalian cells
- C-His
- Wheat Germ
- HEK293
- E.coli
- Mammalian Cell
- Yeast
- In Vitro Cell Free System
- Mamanlian cells
- HEK293T
- E.coli expression system
- His&Fc
- GST
- Non
- His
- His&T7
- Myc&DDK
- His&GST
- His&Fc&Avi
- Flag
- His&SUMO
- Fc
Involved Pathway
Cdh3 involved in several pathways and played different roles in them. We selected most pathways Cdh3 participated on our site, such as Adherens junctions interactions,Cell adhesion molecules (CAMs),Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cdh3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junctions interactions | CDH11,CDH10A,CDH4,CDH9,CTNND1,CDH6,JUP,CDH12,CADM2,CADM2A |
| Cell-cell junction organization | CDH8,PVRL2L,CDH7,CLDN7,CDH17,CDH13,CLDN4,CTNND1,CDH4,CLDN16 |
| Cell-Cell communication | PARVB,KIRREL2,CDH2,LIMS1,CLDN7,CDH24,CD151,TESK1,CDH12,SPTBN1 |
| Cell junction organization | CDH2,PLEC,FBLIM1,INADL,CDH13,CDH7,CLDN16,CDH18A,FERMT2,PARVB |
| Cell adhesion molecules (CAMs) | CNTNAP1,ITGB2L,SPN,MHC1UXA2,NTNG1,CTLA4,MAG,PVRL1B,NCAM1,LRRC4B |
Protein Function
Cdh3 has several biochemical functions, for example, calcium ion binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by Cdh3 itself. We selected most functions Cdh3 had, and list some proteins which have the same functions with Cdh3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TMEM88B,CRYGM2D16,GAGE2B,HAUS6,FADS3,PRR15LB,YIPF6,SRRD,C1orf116,OR2L5 |
| calcium ion binding | RHOT1,F2,NCS1A,EFEMP2A,PCDH12,EGFL6,SULF1,EDIL3,PLA2G2A,DSG2.1 |
Interacting Protein
Cdh3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cdh3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cdh3.
IGF1R;q7ard3_yerpe;y551_bacan;YAP1;AP2M1
Resources
Research Area
Natural Killer Cell (NK Cell)Retinal Stem Cell Markers
Cadherin Superfamily
Cadherins
Related Services
Related Products
References
- Watson, S; Sarris, M; et al. Limbal Dermoid Epithelium Shares Phenotypic Characteristics Common to Both Hair Epidermal and Limbal Epithelial Stem Cells. CURRENT EYE RESEARCH 38:835-842(2013).
- Yoshioka, H; Yamamoto, S; et al. In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy. CANCER IMMUNOLOGY IMMUNOTHERAPY 61:1211-1220(2012).
