CYP1A1
-
Official Full Name
cytochrome P450, family 1, subfamily A, polypeptide 1 -
Overview
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. -
Synonyms
CYP1A1;cytochrome P450, family 1, subfamily A, polypeptide 1;CYP1, cytochrome P450, subfamily I (aromatic compound inducible), polypeptide 1;cytochrome P450 1A1;CP11;P1 450;P450 C;P450DX;AHH;AHRR;Aryl hydrocarbon hydroxylase;CP 11;CP1A1_HUMAN;CYP 1;CYP1;CYPIA1;Cytochrome P1 450 dioxin inducible;Cytochrome P1-450;Cytochrome P1-450 dioxin-inducible;Cytochrome P450 family 1 subfamily A polypeptide 1;Cytochrome P450 form 6;Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1;Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1;Cytochrome P450-C;Cytochrome P450-P1;Flavoprotein-linked monooxygenase;Microsomal monooxygenase;P450 form 6;P450 P1;Xenobiotic monooxygenase;OTTHUMP00000183469;cytochrome P1-450, dioxin-inducible;cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1;P1-450;P450-C
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Dog
- Rainbow trout
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mamanlian cells
- GST
- Non
- His
- Myc&DDK
- His&T7
- His&GST
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
CYP1A1 involved in several pathways and played different roles in them. We selected most pathways CYP1A1 participated on our site, such as AhR pathway,Arachidonic acid metabolism,Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen metabolism | ARSD,NQO1,ARSE,CYP1B1,COMT |
| AhR pathway | CYP1A2,NQO1,PTGES3,CYP1B1,CDKN1B,CDKN1A,JUND,AHR,FLG,CDC37 |
| Cytochrome P450 - arranged by substrate type | CYP8B2,CYP2K18,CYP4F12,CYP2AD3,CYP3C4,CYP4F22,CYP21A2,FDXR,CYP2S1,CYP7A1 |
| Fatty Acid Omega Oxidation | CYP2E1,ADH1A,ADH1C,CYP2A6,ADH1B,ADH7,ADH6,ADH4,CYP2D6,CYP4A11 |
| Benzo(a)pyrene metabolism | AKR1C4,AKR1C2,AKR1A1,CYP3A4,CYP1B1,FAM84B |
| Chemical carcinogenesis | AHA-1,UGT1A9,ADH2-2,GSTP1,UGT2B7,GSTT1,GSTM4,CYP3A5,CYP2B19,GSTO1 |
| Arachidonic acid metabolism | FAAH2B,PLA2G2D,CYP2V1,ALOX15,GGT1A,PLA2G10,CYP2C55,AKR1C3,TBXAS1,CYP2Y3 |
| Biological oxidations | BPNT1,UGT1B2,DPEP1,SULT1ST5,CYP2B6,CYP27B1,CYP17A1,SLC26A1,ACY3.1,CYP4B1 |
Protein Function
CYP1A1 has several biochemical functions, for example, aromatase activity,demethylase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1A1 itself. We selected most functions CYP1A1 had, and list some proteins which have the same functions with CYP1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP26A1,CYP2AD6,NENF,CYP4F18,CYP11A1,CYGB2,CYP2AA2,CYP2C55,CYP2AA1,CYBA |
| steroid hydroxylase activity | CYP2C54,CYP2C37,CYP2A12,CYP46A1.3,CYP2X10.2,CYP2AA1,CYP2AA4,CYP2AD3,CYP2R1,CYP2X7 |
| monooxygenase activity | CYP19A1A,YWHABL,CYP26C1,CYP2C70,CYP2D26,CYP2C9,CYP2C55,CYP1B1,CYP2AD6,CYP8B3 |
| oxidoreductase activity | CYP2AD3,CYP2P9,HIBADHA,YWHAE1,DEGS2,DMGDH,HSD11B1LA,GPX6,EGLN1B,DHRS4L2 |
| oxygen binding | CYP2C55,CYP2R1,HBAD,CYP4B1,CYP2Y3,CYP26A1,CYP2N13,TDO2,CYP2C8,CYP2C54 |
| vitamin D 24-hydroxylase activity | CYP3A4,FAM84B |
| protein binding | ABCA1,PLEKHG2,BST2,NFATC1,FAM96B,DPEP3,AEN,ARL3,TAF1D,NR2C2AP |
| iron ion binding | P4HA3,CYP3C4,CYP2X9,TMLHE,MTRR,CYP2C38,TPH1,HBB-B2,NOS2,CYP1B1 |
| enzyme binding | GSTM3,PLCB1,GOLPH3,FOXO4,HSPA5,DAOA,HAND1,KPNB1,ATP2A2,USP22 |
Interacting Protein
CYP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1A1.
CMTM5
Resources
Related Services
Related Products
References
- Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
- Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).
