CYP11B1
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Official Full Name
cytochrome P450, family 11, subfamily B, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
CYP11B1;cytochrome P450, family 11, subfamily B, polypeptide 1;CYP11B, cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1;cytochrome P450 11B1, mitochondrial;CPN1;FHI;P450C11;CYP11B;CYPXIB1;Cytochrome p450 XIB1;P 450C11;S11BH;Steroid 11 beta hydroxylase;Steroid 11 beta monooxygenase;cytochrome P450C11;cytochrome P-450c11;steroid 11-beta-hydroxylase;steroid 11-beta-monooxygenase;cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Myc&SUMO
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
CYP11B1 involved in several pathways and played different roles in them. We selected most pathways CYP11B1 participated on our site, such as Biological oxidations,Corticotropin-releasing hormone,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP11B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | COASY,AMACR,SPTLC3,RRM1,UGT2A2,GRHPR,AGXT2L1,FUT2,OTC,NDUFAB1A |
| Endogenous sterols | CYP51A1,FDXR,FDX1L,FDX1,CYP27A1,CYP11B2,CYP21A2,CYP1B1,CYP17A1,CYP8B2 |
| Corticotropin-releasing hormone | ECE1,CYP21A2,PARP1,JUND,CRHR1,TCF4,ADRBK2,CRHR2,IVL,CRH |
| Biological oxidations | CYP2J2,CYP46A1,CYP3A7-CYP3AP1,SLC35B3,ADH1C,CYP2AD2,COMT,MTRR,CYP1B1,CYP8B2 |
| Glucocorticoid biosynthesis | CYP17A1,CYP21A2,CYP11B2 |
| Cytochrome P450 - arranged by substrate type | CYP2V1,CYP4A11,CYP4T8,CYP3A4,CYP17A1,CYP2K19,FDXR,CYP1B1,CYP3A5,CYP2K18 |
| Metabolism | SLC25A10,CYP2U1,CERS5,OAZ1,SLC25A21,SLC16A8,GGT6,DHCR24,NAMPT,UGT1B4 |
| Metabolism of lipids and lipoproteins | OSBP,CYP2AD3,ACSF2,CSNK1G2,SLC25A20,MED8,ACOT6,NFYBA,PLIN2,STARD5 |
Protein Function
CYP11B1 has several biochemical functions, for example, corticosterone 18-monooxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP11B1 itself. We selected most functions CYP11B1 had, and list some proteins which have the same functions with CYP11B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP4F11,CYP2K16,SDHC,CYP2C19,CYP1C2,CYP2W1,CYP3A43,CYP2AA3,CYP51A1,DUOX2 |
| steroid 11-beta-monooxygenase activity | CYP11C1,CYP11B2 |
| corticosterone 18-monooxygenase activity | CYP11C1,CYP11B2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | CYP4F11,CYP4F18,MTRR,CYP11C1,POR,CYP11A1,COQ6,NDOR1,CYP4F2,MICAL2 |
| iron ion binding | HBB,CYP1A1,CYP2D6,PPEF1,CYP3A7,FDX1,TMEM195,CYP2AA6,P4HA1B,CYP2J5 |
Interacting Protein
CYP11B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP11B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP11B1.
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References
- Gomez-Sanchez, CE; Qi, X; et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. MOLECULAR AND CELLULAR ENDOCRINOLOGY 383:111-117(2014).
- Nakamura, Y; Maekawa, T; et al. Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies. MOLECULAR AND CELLULAR ENDOCRINOLOGY 392:73-79(2014).
