CYB5A

  • Official Full Name

    cytochrome b5 type A (microsomal)

  • Overview

    The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    CYB5A;cytochrome b5 type A (microsomal);CYB5, cytochrome b 5 , cytochrome b5 (microsomal);cytochrome b5;type 1 cyt-b5;CYB5;MCB5

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Rat
  • Mouse
  • Mus musculus
  • Oryctolagus cuniculus (Rabbit)
  • Bovine
  • Sus scrofa (Pig)
  • Horse
  • E.coli
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • Mammalian cells
  • In Vitro Cell Free System
  • HEK293T
  • E.coli expression system
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Flag
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYB5A-11744H Recombinant Human CYB5A, GST-tagged E.coli Human GST 1-108a.a.
CYB5A-001H Recombinant Human CYB5A Protein, His-tagged Insect Cell Human His 1-108 a.a.
CYB5A-1122R Recombinant Rhesus monkey CYB5A Protein, His-tagged Mammalian Cell Rhesus macaque His
CYB5A-1144C Recombinant Chicken CYB5A Mammalian Cell Chicken His
CYB5A-12352Z Recombinant Zebrafish CYB5A Mammalian Cell Zebrafish His
CYB5A-1700R Recombinant Rat CYB5A Protein Mammalian Cell Rat His
CYB5A-2208H Recombinant Human CYB5A Protein, GST-tagged Wheat Germ Human GST
CYB5A-22H Recombinant Human CYB5A protein, His-tagged E.coli Human His 1-134 a.a.
CYB5A-27555TH Recombinant Human CYB5A, His-tagged E.coli Human His Full L.
CYB5A-27557TH Recombinant Human CYB5A, His-tagged Human His Full L. 1-98 a.a.
CYB5A-7146HCL Recombinant Human CYB5A 293 Cell Lysate HEK293 Human Non
CYB5A-1359R Recombinant Rat CYB5A Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CYB5A-1359R-B Recombinant Rat CYB5A Protein Pre-coupled Magnetic Beads HEK293 Rat
CYB5A-1662HFL Recombinant Full Length Human CYB5A Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
CYB5A-2374HF Recombinant Full Length Human CYB5A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 134 amino acids
Cyb5a-427M Recombinant Mouse Cyb5a Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
CYB5A-694H Recombinant Human CYB5A Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CYB5A-694H-B Recombinant Human CYB5A Protein Pre-coupled Magnetic Beads HEK293 Human
CYB5A-947R Recombinant Rhesus Macaque CYB5A Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CYB5A-947R-B Recombinant Rhesus Macaque CYB5A Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RFL13957GF Recombinant Full Length Chicken Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length (1-138)
RFL16619HF Recombinant Full Length Human Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (2-134)
RFL20890MF Recombinant Full Length Mouse Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (2-134)
RFL23898OF Recombinant Full Length Rabbit Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Oryctolagus cuniculus (Rabbit) His Full L. Full Length of Mature Protein (2-134)
RFL24727BF Recombinant Full Length Bovine Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length of Mature Protein (2-134)
RFL27014RF Recombinant Full Length Rat Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (2-134)
RFL30016SF Recombinant Full Length Pig Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Sus scrofa (Pig) His Full L. Full Length of Mature Protein (2-134)
RFL9499EF Recombinant Full Length Horse Cytochrome B5(Cyb5A) Protein, His-Tagged E.coli expression system Horse His Full L. Full Length of Mature Protein (2-134)

    Involved Pathway

    CYB5A involved in several pathways and played different roles in them. We selected most pathways CYB5A participated on our site, such as Metabolism,Metabolism of vitamins and cofactors,Metabolism of water-soluble vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of vitamins and cofactors ELA2L,PDZD11,GPHNA,SLC2A3,SLC5A6B,ELA2,CTRB1,SLC5A6A,SLC46A1,CYB5R3
    Metabolism MED9,CHP,NUDT3B,UGT1B7,COX14,SLC5A6A,NDUFAF5,ISCUB,STARD5,SLC25A15
    Vitamin C (ascorbate) metabolism CYB5R3,SLC23A2
    Metabolism of water-soluble vitamins and cofactors CTRB1,CBLC-1,SLC52A3,SLC5A6B,SLC46A1,NAMPT,ELA2L,CTRC,GPHNA,SLC19A2
    cytochrome P450 CYP4Z1,CYP4F12,CYP2A7,POR,CYP20A1,CYP2W1,CYP4V2,CYB5B,CYB5R3

    Protein Function

    CYB5A has several biochemical functions, for example, aldo-keto reductase (NADP) activity,cytochrome-c oxidase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5A itself. We selected most functions CYB5A had, and list some proteins which have the same functions with CYB5A. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CYP2P10,ZCCHC16,HMOX1,GALNTL1,ZNF577,ATP13A1,ERMP1,CNOT8,LATS2,ZFP598
    aldo-keto reductase (NADP) activity SDR42E1,HSD3B6,AKR7A3,AKR1B10,HSD3B5,KCNAB2,KCNAB1,AKR1C21,AKR1C4,AKR1B1
    cytochrome-c oxidase activity COX7A1,COX7A2L,SURF1,COX4I1,COX6C,COA6,COX11,COX8A,COX6A1,COX5B
    heme binding CBSA,CYP2D26,CYP2AD2,DGCR8,HBBE1.1,HBB-B2,CYP19A1B,CYP2W1,CYP2C37,CYP2B6
    enzyme binding CASP2,PARP1,UBE2L3,ANK1,UGT1A6A,LYN,TSPAN17,CSF3,STUB1,HSPA6

    Interacting Protein

    CYB5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5A here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5A.

    CYP3A5;TRAF6;UGT1A4;CYP2W1;q9wmx2-pro_0000037550

    Resources

    Research Area

    Notch Pathway

    References

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