CXCR6
-
Official Full Name
Cxcr6 chemokine (C-X-C motif) receptor 6 -
Synonyms
CXCR6;chemokine (C-X-C motif) receptor 6;C-X-C chemokine receptor type 6;CXC-R6;CXCR-6;BONZO;STRL33;BB217514
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Macaca fascicularis
- Macaca nemestrina (Pig-tailed macaque)
- Pan troglodytes
- Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
- Macaca mulatta
- Chlorocebus Aethiops
- HEK293
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- Non
- His
- GST
- His&Fc&Avi
Involved Pathway
CXCR6 involved in several pathways and played different roles in them. We selected most pathways CXCR6 participated on our site, such as Chemokine receptors bind chemokines,Chemokine signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GSK3A,CCL16,PIK3R1,PIK3R3,CXCL12,CCR5,GNB3,CCL17,PLCB4,JAK3 |
| Peptide GPCRs | SSTR4,SSTR1,SSTR5,CX3CR1,TAC4 |
| Class A/1 (Rhodopsin-like receptors) | EDNRAB,OPN1MW2,NMU,PYYA,ADRA1B,UTS2,PTGDR2,ADRB3,OPN1LW,OPN1SW1 |
| Chemokine receptors bind chemokines | CCR1,CCBP2,CXCR7B,CCL19A.2,CCL27,CCL35.2,CCR8,AMCF-II,CCR3,CCR7 |
| GPCR downstream signaling | UTS2D,TRH,SOUL4,CHRM4,ANXA1C,RGS12,MCF2L,RXFP2,CYSLTR1,ADM2A |
| GPCR ligand binding | SCT,ADRA2B,SST1.1,SSTR3,GAL,TAS2R7,GCGB,ADORA1,SETD6,GPR55A |
| G alpha (i) signalling events | OPN5,TAS2R13,SSTR2,RHOL,TAS2R16,NMS,CNR2,CCR9,LPAR2A,HEBP1 |
| Cytokine-cytokine receptor interaction | GM13304,TNFSF10,IL12BA,CD27,BMPR1BB,CXCL16,CXCL12,IL25,CCR6A,Ccl21c |
Protein Function
CXCR6 has several biochemical functions, for example, C-X-C chemokine binding,C-X-C chemokine receptor activity,G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR6 itself. We selected most functions CXCR6 had, and list some proteins which have the same functions with CXCR6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-X-C chemokine binding | CXCR7,HMGB1,CXCR3 |
| coreceptor activity | CXCR7,CD8B,ZP2,TMIGD2,RGMD,CCR8,LRP5,CCR5,NRP1,LY96 |
| G-protein coupled receptor activity | TAS2R113,TAS2R129,CELSR1,GNRHR4,OLFR5,PARAPINOPSINB,OLFR507,TAAR15,GPR45,S1PR2 |
| C-X-C chemokine receptor activity | CXCR5,CXCR7,CCR9A,CXCR4,CXCR2,CXCR4A,CXCR3,CXCR4B,CXCR3.1,CCBP2 |
Interacting Protein
CXCR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR6.
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCChemokine Receptors
Neutrophils
Natural Killer T (NKT) Cells
Regulatory T Cells (Tregs)
T Cell Migration
Monocyte Markers
CXC Chemokine Receptors
Related Services
Related Products
References
- Wehr, A; Baeck, C; et al. Pharmacological Inhibition of the Chemokine CXCL16 Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury. PLOS ONE 9:-(2014).
- Slauenwhite, D; Gebremeskel, S; et al. Regulation of Cytokine Polarization and T Cell Recruitment to Inflamed Paws in Mouse Collagen-Induced Arthritis by the Chemokine Receptor CXCR6. ARTHRITIS & RHEUMATOLOGY 66:3001-3012(2014).
