CSTA
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Official Full Name
cystatin A (stefin A) -
Overview
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. -
Synonyms
CSTA;cystatin A (stefin A);AREI;STF1;STFA;cystatin-A;cystatin AS;Stefin-A;CystatinAS;OTTHUMP00000215569
Recombinant Proteins
- Human
- Rhesus macaque
- Bacillus subtilis
- Rat
- Pig
- E.coli
- Mammalian Cell
- E. coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CSTA involved in several pathways and played different roles in them. We selected most pathways CSTA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CSTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CSTA has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity,protease binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CSTA itself. We selected most functions CSTA had, and list some proteins which have the same functions with CSTA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity | CST2,CST1,CSTL1,CST11,WFDC2,NAIP1,AHSG2,BIRC5,BIRC5B,CARD16 |
| protein binding, bridging | FBXW7,DDX20,SYNM,GOLGA5,WWC1,BFAR,IVL,GATAD2A,FSCN2A,LOR |
| structural molecule activity | KRT76,SPRR1B,SNTG1,EPB41L3B,LMNB2,KRT83,DCTN3,SPRR2H,TUBA1B,COL4A3 |
| protease binding | TNFRSF10A,SERPINC1,TIMP2A,PEO1,SERPINB4,LCN2,CRADD,ADRM1,RYR1,SERPINE1 |
Interacting Protein
CSTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSTA here. Most of them are supplied by our site. Hope this information will be useful for your research of CSTA.
CTSB;USP53;PTN;ZDHHC17;RASSF10;RASSF9;EGFR;CD81;GABARAPL2;MAP1LC3B
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