CRYAA

  • Official Full Name

    crystallin, alpha A

  • Overview

    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

  • Synonyms

    CRYAA;crystallin, alpha A;CRYA1;alpha-crystallin A chain;HSPB4;Heat shock protein beta 4;short form;Acry 1;Acry-1;Alpha crystallin A chain;CRYA 1;CRYAA_HUMAN;Crystallin Alpha 1;Crystallin alpha A;Heat shock protein beta-4;HSPB 4;Zonular Central Nuclear Cataract;OTTHUMP00000109430;crystallin, alpha-1;human alphaA-crystallin (CRYA1)

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • E.Coli or Yeast
  • HEK293
  • Mammalian cells
  • In Vitro Cell Free System
  • HEK293T
  • E. coli
  • Non
  • GST
  • His
  • Flag
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
CRYAA-309H Recombinant Human Crystallin Alpha A E.coli Human Non 1-173 a.a.
CRYAA-1925H Recombinant Human CRYAA Protein, GST-tagged Wheat Germ Human GST
CRYAA-2495C Recombinant Chicken CRYAA Mammalian Cell Chicken His
CRYAA-26676TH Recombinant Human CRYAA E.coli Human Non Full L. 1-173 a.a.
CRYAA-26991TH Recombinant Human CRYAA, His-tagged E.coli Human His 173 amino acids
Cryaa-3344R Recombinant Rat Cryaa, His-tagged E.Coli or Yeast Rat His 173
CRYAA-3933M Recombinant Mouse CRYAA Protein Mammalian Cell Mouse His
CRYAA-9417Z Recombinant Zebrafish CRYAA Mammalian Cell Zebrafish His
CRYAA-7267HCL Recombinant Human CRYAA 293 Cell Lysate HEK293 Human Non
CRYAA-001H Recombinant Human CRYAA Protein E.coli Human 173
CRYAA-1133HFL Recombinant Full Length Human CRYAA Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
CRYAA-1819H Recombinant Human CRYAA Protein (Met1-Ser173), C-His tagged E.coli Human His Met1-Ser173
CRYAA-1994M Recombinant Mouse CRYAA Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CRYAA-1994M-B Recombinant Mouse CRYAA Protein Pre-coupled Magnetic Beads HEK293 Mouse
CRYAA-2127HF Recombinant Full Length Human CRYAA Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 173 amino acids
Cryaa-2325M Recombinant Mouse Cryaa Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
CRYAA-2879H Recombinant Human CRYAA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
CRYAA-5488H Recombinant Human CRYAA protein, His-tagged E. coli Human His 188aa(including fusion tag)
CRYAA-667H Recombinant Human CRYAA Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CRYAA-667H-B Recombinant Human CRYAA Protein Pre-coupled Magnetic Beads HEK293 Human
Cryaa-7175M Recombinant Mouse Cryaa Protein E.coli Mouse 1-175
CRYAA-850H Recombinant Human CRYAA Protein, His-tagged E.coli Human His Asp2-Ser173
Cryaa-851M Recombinant Mouse Cryaa Protein, His-tagged E.coli Mouse His Asp2-Ser173

    Involved Pathway

    CRYAA involved in several pathways and played different roles in them. We selected most pathways CRYAA participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYAA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum EIF2AK4,DAD1,DNAJB1B,BAG2,TXNDC5,MAN1A,SEL1L2,NFE2L2,CALR,RAD23AA

    Protein Function

    CRYAA has several biochemical functions, for example, identical protein binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYAA itself. We selected most functions CRYAA had, and list some proteins which have the same functions with CRYAA. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding C6AST1,ZDHHC20A,ANKFY1,G2E3,SP8A,ZNHIT2,GNAT2,KLF16,BMPR2,ZNF480
    protein binding CFI,KLHL2,MUL1,LAIR2,EIF1AX,THOC4,ARHGAP5,BRCA2,GNS,BBS7
    unfolded protein binding SYVN1,TBCA,HSPD1,LMAN1,AIPL1,HSPE1,PPIB,TAPBP,HSPA1B,APCS
    structural constituent of eye lens CRYGC,CRYGB,CRYGD,HSPB6,CRYGF,CRYBB1,LIM2.4,LIM2.2,CRYABA,ASL1
    identical protein binding MUL1,ATF3,MICU1,PLIN5,RELA,FAS,CEP72,APOE,DESI1,TRIM55

    Interacting Protein

    CRYAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYAA here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYAA.

    CRYAB;CRYGC;CRYBB2

    Resources

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