CRP
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Official Full Name
C-reactive protein, pentraxin-related -
Overview
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009] -
Synonyms
CRP;C-reactive protein, pentraxin-related;PTX1;C-reactive protein;pentraxin 1
Recombinant Proteins
- Mouse
- Rat
- Human
- Cynomolgus
- Chicken
- Zebrafish
- Cattle
- Guinea pig
- Pig
- Rabbit
- Bovine
- Dog
- Rhesus macaque
- Sheep
- Equine
- Canine
- Horse
- Cat
- HEK293
- E.coli
- Mammalian cells
- C-His
- Wheat Germ
- NS0
- Mammalian Cell
- Insect Cell
- Human Cell
- HEK293 cells
- CHO
- E. coli
- Rabbit Serum
- Normal Rhesus Monkey Serum
- In Vitro Cell Free System
- HEK293T
- Human Plasma
- Human Pleural Fluid
- Canine Serum
- Rat Serum
- Plasma
- HEK293F
- His
- Non
- GST
- His&T7
- His&S
- Myc&DDK
- C-His&Flag
- His&Fc&Avi
- Flag
Involved Pathway
CRP involved in several pathways and played different roles in them. We selected most pathways CRP participated on our site, such as Classical antibody-mediated complement activation,Complement cascade,Creation of C4 and C2 activators, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL6-mediated signaling events | LMO4,PIAS3,JUNB |
| Creation of C4 and C2 activators | FCN3,IGKV1-5,IGLC2,IgG3,MASP2,FCN2,FCN1,HBL3,C1rb,IGKC |
| Selenium Pathway | SELK,PRDX3,SAA4,TXNRD2,SAA2-SAA4,DIO2,TXNRD3IT1,SELT,SAA2,PRDX4 |
| Classical antibody-mediated complement activation | C1rb,IGKV1-5,IGKC,IgG3,IGLC2 |
| Complement cascade | FCN1,IGKC,BFB,CFHL3,C1rb,FCN2,CFHL4,CFHL2,GZMM,CFD |
| Innate Immune System | PANX1B,PPAPDC1B,DDX41,TLR10,S100B,FAM49BA,TREX1,CD300E,POLR3F,PPAPDC1A |
| Immune System | SIGLEC15,MGC174155,CR1,LILRB5,NPEPPS,SPSB2,GBP4,EGR1,FCGR1B,EDAR |
| Initial triggering of complement | HBL3,BFB,CFD,FCN3,GZMM,C1rb,FCN1,IgG3,FCN2,MASP2 |
Protein Function
CRP has several biochemical functions, for example, calcium ion binding,choline binding,complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRP itself. We selected most functions CRP had, and list some proteins which have the same functions with CRP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| low-density lipoprotein particle receptor binding | APOB,DNAJA1,APOE,LRPAP1,MESDC2,MMP13,ARRB2,LDLRAP1,APOA5,APOEB |
| low-density lipoprotein particle binding | THBS1,SCARF1,PCSK9,SORL1,CDH13,ANKRA2,MSR1,LDLR,SCARB1,COLEC12 |
| calcium ion binding | SYTL2,MYL1,STIM2,aLA,THBS3A,MMP20,EGFL6,CMLC1,APCS,CDH3 |
| choline binding | SLC5A7,BCHE,CHKA |
| protein binding | ERCC5,VASN,IARS,EIF5,SORCS1,ID3,RTN4,ZNF625,EIF4EA,MRPL20 |
| complement component C1q binding | CALR,C4A,CD93,APCS,C1QBP,PTX3 |
Interacting Protein
CRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRP here. Most of them are supplied by our site. Hope this information will be useful for your research of CRP.
GMPPA;spa;FCN2;FCGR2A;FCGR2C;GLUD1;MAPK3;MAPK1;RPL13A;MAPK8IP2;DGCR14;LAMC3
Resources
Research Area
Renal MarkersAcute Phase Proteins
Inflammatory Mediators
Classical Complement Pathway
Related Services
Related Products
References
- Vashist, SK; Schneider, EM; et al. Graphene-based rapid and highly-sensitive immunoassay for C-reactive protein using a smartphone-based colorimetric reader. BIOSENSORS & BIOELECTRONICS 66:169-176(2015).
- Ahmed, N; Petersson, A; et al. Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis. ACTA ODONTOLOGICA SCANDINAVICA 73:232-240(2015).
