CRH
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Official Full Name
corticotropin releasing hormone -
Overview
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to;stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal;recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including;hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in;peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that;determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels;of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this;protein may act as a trigger for parturition. -
Synonyms
CRH;corticotropin releasing hormone;corticoliberin;corticotropin releasing factor;CRF;corticotropin-releasing factor
Recombinant Proteins
- Human
- Bacillus subtilis
- Rat
- Chicken
- Mouse
- E.coli
- E. coli or Yeast
- Wheat Germ
- Mammalian Cell
- HEK293
- His
- GST
- T7
- His&GST
- Non
- His&Fc&Avi
- His&KSI
Involved Pathway
CRH involved in several pathways and played different roles in them. We selected most pathways CRH participated on our site, such as Alcoholism,Class B/2 (Secretin family receptors),Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Corticotropin-releasing hormone | IVL,CASP12,TFAP2A,CYP11A1,TCF4,PARP1,JUND,TRIM28,CYP11B1,KRT14 |
| Class B/2 (Secretin family receptors) | PTHRP2,GCGA,ADM2,ADCYAP1B,GNB3B,GCGB,GNB5B,EMR3,CALCB,PTH2 |
| GPCR ligand binding | OPN4,PMCH,GPR18,GPR39,OXGR1A.3,CNR2,CHRM1,EDNRB,UTS2D,RGS1 |
| Myometrial Relaxation and Contraction Pathways | IGFBP5,CRHR1,RGS6,RGS5,RGS11,CRCP,RGS14,GUCA2A,PKIB,MAFF |
| G alpha (s) signalling events | CGA,SCT,PTH,RLN2,VIP2,ADCYAP1,ADM2,PTHRP2,GHRH,GCGB |
| Alcoholism | CREB5,HIST1H2BQ,HDAC2,HIST1H3A,HDAC7,CREB3,HIST1H2BK,GNAI2,CAMKK1,HIST1H4E |
| GPCR downstream signaling | DGKQ,DGKG,RHOB,DRD2,KALRN,OBSCN,DCLRE1B,GPR4,GHRH,OXGR1A.1 |
| Long-term depression | RAF1,GNA11,NOS1,GNAO1,PPP2R1B,PLCB4,PRKG1,PLCB1,KRAS,GNAZ |
Protein Function
CRH has several biochemical functions, for example, corticotropin-releasing hormone receptor 1 binding,corticotropin-releasing hormone receptor 2 binding,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRH itself. We selected most functions CRH had, and list some proteins which have the same functions with CRH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide hormone activity | CORT,PYYA,NTS,NPY,POMCA,GAL,QRFP,PYY,PNOC,AVP |
| protein binding | ELP4,SORBS3,HPSE,VAMP4,CSF2RB,SMOC1,RTKN,ROR1,TMEM8B,SRSF2 |
| receptor binding | TNFSF15,FKBP1B,BMP3,MBL2,IZUMO1,LAMA3,LRP6,MCHR1,ECI2,TRIM24 |
| hormone activity | PRL3B1,PRL7D1,FAM132A,FSD1,RETNLB,PRL4A1,Retnla,GALP,IAPP,PTHLHA |
| corticotropin-releasing hormone receptor 1 binding | GNAO1A,GNAO1,GNAO1B,GNAS,UCN |
| corticotropin-releasing hormone receptor 2 binding | UCN,UCN3L,UCN3,UCN2 |
Interacting Protein
CRH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRH here. Most of them are supplied by our site. Hope this information will be useful for your research of CRH.
CRHR1;KRT31
Resources
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References
- Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
- Topp, MS; Gokbuget, N; et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. LANCET ONCOLOGY 16:57-66(2015).
