CNOT7
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Official Full Name
CCR4-NOT transcription complex, subunit 7 -
Overview
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. -
Synonyms
CNOT7;CCR4-NOT transcription complex, subunit 7;CAF1;CCR4-NOT transcription complex subunit 7;BTG1 binding factor 1;BTG1-binding factor 1;CAF 1;CAF-1;Carbon catabolite repressor protein (CCR4) associative factor 1;CCR4 associated factor 1;CCR4 NOT transcription complex subunit 7;CCR4-associated factor 1;CNOT 7;CNOT7_HUMAN;hCAF 1;hCAF1;OTTHUMP00000122444;OTTHUMP00000225203;OTTHUMP00000225205;carbon catabolite repressor protein (CCR4)-associative factor 1;hCAF-1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
CNOT7 involved in several pathways and played different roles in them. We selected most pathways CNOT7 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | DIS3,BTG4,HSPA9,PFKL,PABPC3,CNOT10,SKIV2L,SKIV2L2,DDX6,PABPC5 |
Protein Function
CNOT7 has several biochemical functions, for example, 3-5-exoribonuclease activity,RNA binding,exoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT7 itself. We selected most functions CNOT7 had, and list some proteins which have the same functions with CNOT7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | DDX11,MIF4GDB,RPL27A,SNRPE,TEP1,RPS9,DKC1,BAZ2A,XPO1,EIF5A |
| protein binding | GLYR1,PPP3CA,TGFA,U2AF1,FSHR,C4orf19,RC3H2,RWDD3,LOC729991,ZNF131 |
| exoribonuclease activity | CNOT6,EXOSC10 |
| 3-5-exoribonuclease activity | CNOT8,DIS3L2,EXOSC4,EXOSC2,ERI3,DIS3,USB1,C16orf57,TOE1,DIS3L |
| transcription factor activity, sequence-specific DNA binding | SKINT8,MYCLB,MLXIPL,CNOT8,SHOX,HOXC8A,FOXB1B,PRDM1,NEUROG1,BLF |
| metal ion binding | CSRP1A,ING5B,ARHGEF28,B3GAT2,ZFP516,RFESD,SDHB,MYLIPB,FTH1A,PRIM2 |
| poly(A)-specific ribonuclease activity | CNOT8,PAN2,TOE1,CNOT6,PDE12,PARN,CNOT6L |
| signal transducer activity | VMN1R46,PLCL2,OLFR497,MRGPRB8,PTH1RB,TMTOPS2B,LPAR2B,IL13RA2,V2RX1,HTR5AL |
Interacting Protein
CNOT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT7.
TOB1;CNOT1;BTG2;BTG1
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