CLDN6
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Official Full Name
claudin 6 -
Overview
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. -
Synonyms
CLDN6;claudin 6;claudin-6;skullin
Recombinant Proteins
- Human
- Rhesus monkey/Cynomolgus
- Cynomolgus
- Mouse
- HEK293
- Insect Cell
- Insect cells
- Wheat Germ
- Baculovirus-Insect cells
- In Vitro Cell Free System
- Wheat Germ (in vitro)
- In vitro E. coli expression system
- Non
- Flag
- His&Strep
- His
- His&Flag&GFP
- His&Twin Strep
- N-His&C-Avi-Flag
- GST
- GFP
- His&SUMO
Involved Pathway
CLDN6 involved in several pathways and played different roles in them. We selected most pathways CLDN6 participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | TIGIT,CD8A,PVRL3B,VCAN,HLA-DRB1,HLA-F,PRPSAP2,GLYCAM1,CD58,ITGB2L |
| Tight junction | RAB3B,CLDN5B,LLGL2,CLDND,GNAI3,MRAS,CLDN11B,VAPAL,CLDN9,CLDN15LB |
| Hepatitis C | RIPK1,BRAF,CLDN11,TNF,IRF1,ARAF,PIAS1,SOS1,MAPK12,IFNAR1 |
| Leukocyte transendothelial migration | CLDN10,NIPAL1,ARHGAP35,NOX3,PIK3CD,ACTN1,RAP1B,THY1,PIK3R5,ITGB1 |
Protein Function
CLDN6 has several biochemical functions, for example, identical protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN6 itself. We selected most functions CLDN6 had, and list some proteins which have the same functions with CLDN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | NES,PLP1,SPRR2E,NEFMB,CLTC,CLDN8,KRT6A,KRT19,CYT1,MAP7 |
| identical protein binding | SNX8,LCK,TTR,TYROBP,DIAPH1,TPD52L1,AGER,ALS2CL,C10orf88,LYZ |
Interacting Protein
CLDN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN6.
Resources
Research Area
Early Endodermal Lineage MarkersEpithelial Cell Markers and Intracellular Molecules
Claudins
Endodermal Lineage Markers
Tight Junctions
Related Services
Related Products
References
- Micke, P; Mattsson, JSM; et al. Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer. INTERNATIONAL JOURNAL OF CANCER 135:2206-2214(2014).
- Haid, S; Grethe, C; et al. Isolate-Dependent Use of Claudins for Cell Entry by Hepatitis C Virus. HEPATOLOGY 59:24-34(2014).
