CKMT2
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Official Full Name
creatine kinase, mitochondrial 2 (sarcomeric) -
Overview
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
CKMT2;creatine kinase, mitochondrial 2 (sarcomeric);creatine kinase S-type, mitochondrial;SMTCK;CKMT 2;mitochondrial;Basic-type mitochondrial creatine kinase;CPK;Creatine kinase mitochondrial 2;Creatine kinase mitochondrial 2 (sarcomeric);Creatine kinase S-type;KCRS_HUMAN;Mib CK;Mib-CK;S-MtCK;Sarcomeric mitochondrial creatine kinase
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Yeast
- GST
- His
- Non
- His&Fc&Avi
- N-His&C-Myc
- Myc&DDK
Involved Pathway
CKMT2 involved in several pathways and played different roles in them. We selected most pathways CKMT2 participated on our site, such as Arginine and proline metabolism,Creatine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CKMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ST6GALNAC5,B4GALT4,P4HA3,TAT,NDUFS8B,ACAD8,ACSM2,SDHC,PYCR2,COX6A1 |
| Metabolism of polyamines | CKMB,AZIN2,PAOX,CKMT2A,OAZ2,SAT1B,SLC25A15A,OAZ1,SLC6A12,CKB |
| Metabolism | AADAC,SAT1B,DTYMK,FAAH2,MMADHC,STARD5,CYP4F22,CYP26A1,MOCOS,KCNC2 |
| Creatine metabolism | SLC6A12,SLC6A8,CKM,LSM1,CKB,CKBA,CKMB,SLC6A7,CKMT1B,CKMT2A |
| Arginine and proline metabolism | Ckmm,DAO,P4HA1A,SAT1A.2,ALDH2.2,ARG2,CKBB,PRODH,CKB,PYCR1B |
| creatine-phosphate biosynthesis | CKMT1B,CKB |
| Metabolism of amino acids and derivatives | GLS2B,AZIN1A,SLC25A2,ALDH9A1A.2,PPM1K,AZIN2,SLC25A21,AHCY,DAO,SAT1B |
Protein Function
CKMT2 has several biochemical functions, for example, ATP binding,creatine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CKMT2 itself. We selected most functions CKMT2 had, and list some proteins which have the same functions with CKMT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| creatine kinase activity | CKM,CKB,CKMT1A,CKBB,CKMT1,MAP4K4,Ckmm,CKMT1B |
| ATP binding | CDC6,GSK3A,MYO9B,NDUFA13,MYH7,RAD17,SMARCA4,DNAJA3,MOV10B.1,PAPOLG |
Interacting Protein
CKMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CKMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CKMT2.
ELN;UNC119;RIF1;ABHD6;TMED9;OLFML3
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