CITED2
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Official Full Name
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -
Overview
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
CITED2;Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2;cbp/p300-interacting transactivator 2;Cbp/p300 interacting transactivator 2;Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2;CITE2_HUMAN;CITED 2;MRG 1;MRG-1;MRG1;MSG related protein 1;MSG-related protein 1;P35srj;MSG1-related gene 1;melanocyte-specific gene 1-related gene 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CITED2 involved in several pathways and played different roles in them. We selected most pathways CITED2 participated on our site, such as HIF-1-alpha transcription factor network,HIF-2-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CITED2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF-1-alpha transcription factor network | PLIN2,GATA2,ENG,CP,COPS5,NDRG1,NPM1,ADM,EGLN3,TFF3 |
| HIF-2-alpha transcription factor network | HIF1AN,EGLN3,EGLN2 |
Protein Function
CITED2 has several biochemical functions, for example, LBD domain binding,RNA polymerase II transcription coactivator activity,RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CITED2 itself. We selected most functions CITED2 had, and list some proteins which have the same functions with CITED2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CHRNA5,RAP1GAP,AKIP1,MIIP,ZNF3,MKRN3,ABL1,POLR3GL,GNA12,EIF4A1 |
| LBD domain binding | PROX1,MED1,CITED1 |
| histone acetyltransferase binding | HIF1A,GLI3,CREB1,TAF7,KAT2B,TRIM68,TRP53,ZBTB7A,NR4A3,TAF7L |
| RNA polymerase II transcription corepressor activity | SIN3B,SIN3AA,TFAP2B,TBX15,ELANE,UXT,HEYL,HDGF,N4BP2L2,NFIB |
| RNA polymerase II transcription coactivator activity | PSIP1,MYOCD,ISL1,SMARCA2,MEF2A,TRIM28,TFAP2B,TBX20,NCOA1,SOX12 |
| chromatin binding | SKIL,TRP63,HOXD13,SOX9A,HDAC7,URI1,SMARCA2,MLH3,GLI2,PARP1 |
| transcription coactivator activity | TUBB3,ESR2,MED6,PCBD1,MAML1,MTDH,NPM1,THRAP3,ZEB1,VGLL1 |
| transcription corepressor activity | CTBP2,TFAP2B,SKIL,ARHGAP35,HOMEZA,CTCF,CDYL,SUFU,DNMT3B,BRD7 |
| transcription factor activity, sequence-specific DNA binding | FOXJ1A,ZFP770,VAV1,MAFGA,FOXK2,FOXP2,CIR1,ZNF334,ZKSCAN17,EGR2B |
Interacting Protein
CITED2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CITED2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CITED2.
HNF4A;EP300;TFAP2C;TFAP2A;TFAP2B;tsr;q9x365_bacan
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