CDKN3
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Official Full Name
cyclin-dependent kinase inhibitor 3 -
Overview
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CDKN3;cyclin-dependent kinase inhibitor 3;CDI1;CDK2 associated dual specificity phosphatase;cyclin dependent kinase inhibitor;KAP;kinase associated phosphatase;kinase-associated phosphatase;Cdk-associated protein phosphatase;cyclin-dependent kina
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- Wheat Germ
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- Yeast
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
CDKN3 involved in several pathways and played different roles in them. We selected most pathways CDKN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CDKN3 has several biochemical functions, for example, protein binding,protein serine/threonine phosphatase activity,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN3 itself. We selected most functions CDKN3 had, and list some proteins which have the same functions with CDKN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/serine/threonine phosphatase activity | DUSP19A,PTP4A3,DUSP10,DUSP22A,DUSP5,MTMR2,PTP4A2B,SACM1LA,PTPMT1,DUSP13 |
| protein tyrosine phosphatase activity | CDC14A,EYA2,PTPRO,PTPN22,PTPRA,PTPN3,SSH1,MTMR7A,PALD1A,TPTE |
| protein binding | MED31,INPPL1,SLAMF7,ABTB1,POLI,FBXL3,COG4,USP18,KLHL2,HIST1H2AM |
| protein serine/threonine phosphatase activity | PPM1DA,EPM2A,PPP2R2A,PPM1G,LCK,PPP5C,PPA2,CDC14A,PPM1DB,PPM1NB |
Interacting Protein
CDKN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN3.
CDK2;CDC28;CDK1;CDK3
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