CDKN2B
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Official Full Name
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -
Overview
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
CDKN2B;cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4);P15;MTS2;TP15;CDK4I;INK4B;p15INK4b;cyclin-dependent kinase 4 inhibitor B;MTS-2;p14-INK4b;p14_INK4B;p15-INK4b;p15_INK4B;CDK4B inhibitor;p14_CDK inhibitor;p15 CDK inhibitor;CDK inhibitory protein;multiple tumor suppressor 2;cyclin-dependent kinases 4 and 6 binding protein
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- His&T7
- Non
- His&SUMO
- His&Fc&Avi
- His&Myc
- Myc&DDK
Involved Pathway
CDKN2B involved in several pathways and played different roles in them. We selected most pathways CDKN2B participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | PIK3CD,SOD2,INSR,SGK2A,PRKAG3,TNFSF10,PIK3R5,KLF2B,PDPK1,PIK3R1 |
| Cell cycle | DYRK1A,CEP63,CDC16,BLZF1,MAU2,DSN1,NCAPH2,CUL1B,E2F2,YWHAB |
| G1 Phase | CDKN2D,E2F4,PIANP,CDKN2C,CKS1B |
| Cellular responses to stress | WIPI2,TXN2,ATG4A,MAP1LC3B,EHMT2,LAMTOR1,MAP1LC3C,AGO3,ATG9A,KDM6B |
| Cellular Senescence | MOV10,ERF,LMNB1,CDK4,PHC2,CDK6,MAPKAPK2B,BMI1B,EED,RAD50 |
| Cell Cycle, Mitotic | BORA,HIST4H4,CENPO,ACTR1A,APITD1,CDKN2A,CCDC99,CEP290,NUP50,KIF20A |
| Cyclin D associated events in G1 | CDK7,PIANP,E2F4,CKS1B,CDKN2D,CDKN2C |
Protein Function
CDKN2B has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2B itself. We selected most functions CDKN2B had, and list some proteins which have the same functions with CDKN2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ITM2B,FAM109A,FAM21C,UIMC1,P4HB,APOD,NOC2L,TIMM21,COX6B2,CARM1 |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | INCA1,HEXIM2,Casp3,CDKN1D,CDKN1B,CDKN1BB,HEXIM1,CDKN1BA,CDKN2D,CDKN1A |
| protein kinase binding | TTN,HIF1A,PPP1R12C,USF1,USP37,JTB,PLCG1,AP2A1,GRB2,DOK7 |
Interacting Protein
CDKN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2B.
CDK4;CDK6;80125;TRAF1
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