CDKN1B
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Official Full Name
cyclin-dependent kinase inhibitor 1B (p27, Kip1) -
Overview
Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle. -
Synonyms
CDKN1B;cyclin-dependent kinase inhibitor 1B (p27, Kip1);KIP1;MEN4;CDKN4;MEN1B;P27KIP1;cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;p27Kip1;OTTHUMP00000195098;OTTHUMP00000195099;kinase inhibitory protein (Kip1)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- E. coli
- Insect Cell
- Wheat Germ
- E.coli
- Mammalian Cell
- Human
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- N-His
- Flag
- GST
- His&T7
- His
- His&MBP
- Non
- N-GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CDKN1B involved in several pathways and played different roles in them. We selected most pathways CDKN1B participated on our site, such as AKT phosphorylates targets in the cytosol,Adaptive Immune System,AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | CYP1B1,CDC37,AHRR,AHR,JUND,NQO1,CYP1A2,CYP1A1,EGFR,JUN |
| Cell Cycle, Mitotic | DNA2,DCTN3,ERCC6L,GORASP1,CENPH,ZWINT,SGOL1,POLD3,CDKN2D,STAG1 |
| AKT phosphorylates targets in the cytosol | CHUK,AKT3,CDKN1A |
| C-MYB transcription factor network | PPID,MYC,LECT2,COL1A2,ELANE,CSF1R,CDK6,PTCRA,CREBBP,TOM1 |
| Cell Cycle Checkpoints | TP53BP1,MCM10,HTATIP,HIST3H2BB,RAD1,BRE,RAD9B,RAD9A,CDK2,HIST4H4 |
| Adaptive Immune System | CYBB,LILRB3,SPSB2,RNF25,TREML1,BLMH,LRSAM1,UBE2J2,DCTN3,KIR2DS2 |
| Cell cycle | CDK7,DCTN3,WRAP53,SPC24,DYNC1I2,SMAD2,DMC1,SMAD4,KIF20A,PMF1 |
Protein Function
CDKN1B has several biochemical functions, for example, Hsp70 protein binding,chaperone binding,cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1B itself. We selected most functions CDKN1B had, and list some proteins which have the same functions with CDKN1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chaperone binding | DNAJB5,CLU,RNF207,DNAJA2L,DNAJA2,ST13,DLST,TSACC,VWF,HLA-B |
| contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process | NKX3-1,NKX3 |
| protein binding | CSPP1,SP100,GPX3,VDR,NDFIP1,BBS7,ZNF550,RPTOR,RAB25,TP53BP1 |
| protein phosphatase binding | SKAP1,VCAN,JUPA,CSF1R,LCK,HSF4,MET,MVP,STAT6,ANAPC7 |
| protein complex binding | DRD1A,PPARA,CPS1,FYB,PDCL,RIPK3,UQCRC2,IGBP1,FADD,HSPD1 |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN1C,CDKN1BB,Casp3,CDKN2A,HEXIM2,CDKN1BA,CDKN2D,CDKN1D,CDKN1A,INCA1 |
| Hsp70 protein binding | L7RN6,GPR37,DNAJC2,PPID,DNAJB1,BAG6,PARK2,STUB1,RNF207,TFRC |
| transforming growth factor beta receptor, cytoplasmic mediator activity | ENG |
Interacting Protein
CDKN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1B.
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References
- Cattoretti, G; et al. MYC expression and distribution in normal mature lymphoid cells. JOURNAL OF PATHOLOGY 229:430-440(2013).
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
