CDH5

  • Official Full Name

    cadherin 5, type 2 (vascular endothelium)

  • Overview

    This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

  • Synonyms

    CDH5;cadherin 5, type 2 (vascular endothelium);7B4;CD144;cadherin-5;7B4 antigen;VE-cadherin;cd144 antigen;endothelial-specific cadherin;vascular endothelial cadherin;cadherin 5, type 2, VE-cadherin (vascular epithelium)

Recombinant Proteins

  • Mouse
  • Human
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • Rat
  • Mus musculus
  • Sus scrofa (Pig)
  • HEK293
  • E.coli
  • Mammalian cells
  • Wheat Germ
  • Mammalian Cell
  • Insect Cell
  • Human Cell
  • E.coli expression system
  • His
  • His&Fc
  • GST
  • Fc
  • Non
  • hIgG4
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
Cdh5-2284M Recombinant Mouse Cdh5 protein, His-tagged HEK293 Mouse His Met1-Ala592
CDH5-3245H Recombinant Human CDH5 protein, His&hFc-tagged HEK293 Human His&Fc Met1-Gln593
CDH5-3677H Recombinant Human CDH5 protein, GST-tagged E.coli Human GST 54-241 aa
CDH5-3894H Recombinant Human CDH5 protein, His-tagged E.coli Human His 54-241 aa
CDH5-148M Active Recombinant Mouse CDH5, Fc Chimera Mammalian cells Mouse Fc 46-592 a.a.
CDH5-501H Active Recombinant Human CDH5 protein, His-tagged HEK293 Human His Asp48-Gln599
CDH5-0991H Recombinant Human CDH5 Protein, GST-Tagged Wheat Germ Human GST
CDH5-1182Z Recombinant Zebrafish CDH5 Mammalian Cell Zebrafish His
CDH5-1573R Recombinant Rhesus Monkey CDH5 Protein HEK293 Rhesus macaque Non 28-598 a.a.
CDH5-1574R Recombinant Rhesus Monkey CDH5 Protein, hIgG1-tagged HEK293 Rhesus macaque Fc 28-598 a.a.
CDH5-1575R Recombinant Rhesus Monkey CDH5 Protein, hIgG4-tagged HEK293 Rhesus macaque hIgG4 28-598 a.a.
CDH5-1696H Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His Mammalian cells Human His 1-593 a.a.
CDH5-31200TH Recombinant Human CDH5 Wheat Germ Human Non 100 amino acids
Cdh5-364M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell Mouse His
CDH5-5800C Recombinant Chicken CDH5 Mammalian Cell Chicken His
CDH5-6862H Recombinant Human CDH5 protein, His & T7-tagged E.coli Human His&T7 Gly69~Gly391
Cdh5-6863M Recombinant Mouse Cdh5 protein, His & T7-tagged E.coli Mouse His&T7 Gly67~Gly390
Cdh5-6864R Recombinant Rat Cdh5 protein, His & T7-tagged E.coli Rat His&T7 Gly59~Gly382
Cdh5-8758R Recombinant Rat Cdh5, His tagged Human Cell Rat His&Fc 1-585 a.a.
CDH5-1201RCL Recombinant Rat CDH5 cell lysate Human Cell Rat Non
CDH5-2213HCL Recombinant Human CDH5 cell lysate Human Cell Human Non
CDH5-2570MCL Recombinant Mouse CDH5 cell lysate Human Cell Mouse Non
CDH5-003H Recombinant Human CDH5 Protein, C-His-tagged E.coli Human His
CDH5-0675H Recombinant Human CDH5 Protein (Val68-Thr307), N-His tagged E.coli Human His Val68-Thr307
CDH5-081H Recombinant Human cadherin 5 Protein, Tag Free HEK293 Human Non 48-599aa
CDH5-1145R Recombinant Rat CDH5 protein(Met1-Gln585), His-tagged HEK293 Rat His Met1-Gln585
CDH5-128M Recombinant Mouse CDH5 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CDH5-128M-B Recombinant Mouse CDH5 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CDH5-2641H Recombinant Human CDH5 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CDH5-2641H-B Recombinant Human CDH5 Protein Pre-coupled Magnetic Beads HEK293 Human
CDH5-3854H Recombinant Human CDH5 Protein (Met1-Gln593), C-His tagged Mammalian cells Human His Met1-Gln593
Cdh5-7173M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell Mouse His 25-599
RFL12043HF Recombinant Full Length Human Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (48-784)
RFL2498MF Recombinant Full Length Mouse Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (46-784)
RFL7349SF Recombinant Full Length Pig Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system Sus scrofa (Pig) His Full L. Full Length of Mature Protein (45-782)

    Involved Pathway

    CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions,Cell adhesion molecules (CAMs),Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell-Cell communication PLEC,TESK1,COL17A1A,KIRREL2,CDH9,DSCAML1,CLDN20,COL17A1,SPTBN1,PVRL1A
    Adherens junctions interactions CDH18A,PVRL1A,CDH6,CDH9,CDH12,CDH13,CDH8,CDH17,CADM2B,JUP
    Cell adhesion molecules (CAMs) Ntng2,CLDN11,CLDNB,NLGN2A,NLGN3A,CD276,CLDN10,CLDN11A,ICAM3,CLDNK
    Cell-cell junction organization CDH11,CLDN20,CDH6,PVRL2L,CTNND1,CDH9,CLDN3,JUPA,CDH4,CDH3
    Signal Transduction OR52B4,RDH14,ARHGAP20,NPS,SOX4A,ARHGAP4A,LGR4,ARHGEF17,PRC1,SDR16C5
    Leukocyte transendothelial migration ITGA4,ACTN1,PRKCA,MAPK12,RAP1A,VAV2,PIK3CG,CLDN5,RHOH,PIK3CA
    Cell junction organization PVRL1A,FBLIM1,CLDN3,CDH7,CDH12,CDH10,CD151,CDH24,CADM2,LIMS1

    Protein Function

    CDH5 has several biochemical functions, for example, beta-catenin binding,calcium ion binding,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding MYL2B,CLEC3B,PLA2G2F,PVALB1,CALB2A,EFCAB4A,PCDH1G22,ANXA7,EFCAB7,KCNIP3B
    beta-catenin binding PTPRJ,PARK2,CHD8,EP300,SMAD7,DVL3,ESR1,DACT2,CTNNA3,HDAC6
    ion channel binding ACTN4,DIAPH1,KCNE2,LRRK2,YWHAH,ASPH,RNF207,FGF12,AKAP6,TCAP
    protein binding NID2,UBL4A,FAM32A,RNF180,SERPINA5,DIS3L,RILP,IL10RB,KHDC1A,MAP2K6
    receptor binding NXPH3,GSTK1,TNFSF12,MIF,PTK6B,CSNK2B,POU2F1,PLG,ABL1,SRPX2
    protein phosphatase binding MAP3K5,KCNN4,ERBB2,FLT4,LCK,EIF2AK3,DLG4,SNX3,RPA3,PIK3R1

    Interacting Protein

    CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.

    CTNNB1;PARD6A;KDR;PARD3;SHC1;Ctnnd1

    Resources

    Research Area

    Endothelial Cell Markers
    Cardiac Stem Cell Markers
    Hemangioblast Markers
    Myogenesis Markers
    Other CD Antigen
    Endothelial Cell Differentiation Markers
    Adherens Junction Proteins in Endothelial Cells
    Adherens Junction Proteins in VSMC
    Cadherin Superfamily
    Smooth Muscle Cell Markers
    Mesodermal Lineage Markers
    Cadherins

    References

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