CDH2
-
Official Full Name
cadherin 2, type 1, N-cadherin (neuronal) -
Overview
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008] -
Synonyms
CDH2;cadherin 2, type 1, N-cadherin (neuronal);CDHN;NCAD;CD325;CDw325;cadherin-2;N-cadherin 1;neural cadherin;neural-cadherin;cadherin 2, N-cadherin (neuronal);calcium-dependent adhesion protein, neuronal
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Rhesus macaque
- Zebrafish
- Bovine
- Mus musculus
- Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
- Rhinolophus ferrumequinum (Greater horseshoe bat)
- Callithrix jacchus (White-tufted-ear marmoset)
- Human Cell
- HEK293
- E.coli
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Rabbit
- HEK293T
- E.coli expression system
- Fc
- His
- GST
- His&Flag&StrepII
- Non
- hIgG4
- His&Fc&Avi
- C-His&hFc
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDH2-315H |
Recombinant Human CDH2, His-Fc tagged
|
Human Cell | Human | Fc | 1-724 a.a. | |
| CDH2-2191H | Recombinant Human CDH2 protein(Met1-Ala724), His-tagged | HEK293 | Human | His | 1-724 a.a. | |
| CDH2-4938H | Recombinant Human CDH2 protein, GST-tagged | E.coli | Human | GST | 421 - 535 aa | |
| CDH2-316H |
Active Recombinant Human CDH2, Fc tagged
|
Mammalian cells | Human | Fc |
|
|
| Cdh2-592M |
Active Recombinant Mouse Cdh2 Protein, Fc Chimera
|
Mammalian cells | Mouse | Fc |
|
|
| CDH2-0983H | Recombinant Human CDH2 Protein, His-Flag-StrepII-Tagged | Human Cell | Human | His&Flag&StrepII | 160-724 a.a. |
|
| CDH2-0984H | Recombinant Human CDH2 Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| CDH2-1134C | Recombinant Chicken CDH2 | Mammalian Cell | Chicken | His |
|
|
| CDH2-1290R | Recombinant Rat CDH2 Protein | Mammalian Cell | Rat | His |
|
|
| CDH2-1740R | Recombinant Rhesus Monkey CDH2 Protein | HEK293 | Rhesus macaque | Non | 160-724 a.a. |
|
| CDH2-1741R | Recombinant Rhesus Monkey CDH2 Protein, hIgG1-tagged | HEK293 | Rhesus macaque | Fc | 160-724 a.a. |
|
| CDH2-1742R | Recombinant Rhesus Monkey CDH2 Protein, hIgG4-tagged | HEK293 | Rhesus macaque | hIgG4 | 160-724 a.a. |
|
| CDH2-271H | Recombinant Human CDH2 Protein, His-tagged | Insect Cell | Human | His | 1-724 a.a. |
|
| CDH2-28769TH | Recombinant Human CDH2 | Wheat Germ | Human | Non | 100 amino acids |
|
| CDH2-304M | Recombinant Mouse Cdh2, LEVLFQ tagged | Human Cell | Mouse | His | 1-724 a.a. |
|
| CDH2-7023H | Recombinant Human CDH2 protein, His-tagged | E.coli | Human | His | Ser685~Asp784 |
|
| Cdh2-7024M | Recombinant Mouse Cdh2 protein, His-tagged | E.coli | Mouse | His | Leu45~His238 |
|
| Cdh2-7025R | Recombinant Rat Cdh2 protein, His-tagged | E.coli | Rat | His | Ser563~Ser685 |
|
| Cdh2-7026R | Recombinant Rat Cdh2 protein, His-tagged | E.coli | Rat | His | Pro144~Asn273 |
|
| CDH2-8707Z | Recombinant Zebrafish CDH2 | Mammalian Cell | Zebrafish | His |
|
|
| Cdh2-8757R | Recombinant Rat Cdh2, His tagged | Human Cell | Rat | His | 1-724 a.a. |
|
| CDH2-87H | Recombinant Human Cadherin 2, Type 1, N-cadherin (Neuronal) | E.coli | Human | Non | 741-907 a.a. |
|
| CDH2-971MCL | Recombinant Mouse CDH2 cell lysate | Human Cell | Mouse | Non |
|
|
| CDH2-980HCL | Recombinant Human CDH2 cell lysate | Human Cell | Human | Non |
|
|
| CAB11508RH | Rabbit Anti-Human Cadherin 2, type 1, N-cadherin Monoclonal Antibody | Rabbit | Human | Non |
|
|
| CDH2-001H | Recombinant Human CDH2 Protein, His-tagged | E.coli | Human | His |
|
|
| CDH2-1306H | Recombinant Human CDH2 Protein (Asp160-Ala724), N-His tagged | E.coli | Human | His | Asp160-Ala724 |
|
| Cdh2-21M | Recombinant Mouse Cdh2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| Cdh2-21M-B | Recombinant Mouse Cdh2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| CDH2-2321M | Recombinant Mouse CDH2 protein(Met1-Ala724) | HEK293 | Mouse | Non | Met1-Ala724 |
|
| CDH2-2360H | Recombinant Human CDH2 protein(Met1-Ala724), His&hFc-tagged | HEK293 | Human | C-His&hFc | Met1-Ala724 |
|
| CDH2-3153H | Recombinant Human CDH2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| CDH2-3848H | Recombinant Human CDH2 Protein (Met1-Ala724), C-His tagged | Mammalian cells | Human | His | Met1-Ala724 |
|
| CDH2-44H | Recombinant Human CDH2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| CDH2-44H-B | Recombinant Human CDH2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| CDH2-6651H | Recombinant Human CDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| Cdh2-861M | Recombinant Mouse Cdh2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| CDH2-877HFL | Recombinant Full Length Human CDH2 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| CDH2-948R | Recombinant Rat CDH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| CDH2-948R-B | Recombinant Rat CDH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| RFL12778HF | Recombinant Full Length Human Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (160-906) |
|
| RFL13992BF | Recombinant Full Length Bovine Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (131-877) |
|
| RFL25845GF | Recombinant Full Length Chicken Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length of Mature Protein (165-912) |
|
| RFL26809MF | Recombinant Full Length Mouse Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (160-906) |
|
| RFL30074OF | Recombinant Full Length Otolemur Garnettii Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) | His | Full L. Full Length of Mature Protein (160-906) |
|
| RFL35825RF | Recombinant Full Length Rhinolophus Ferrumequinum Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Rhinolophus ferrumequinum (Greater horseshoe bat) | His | Full L. Full Length of Mature Protein (160-906) |
|
| RFL6351CF | Recombinant Full Length Callithrix Jacchus Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | Callithrix jacchus (White-tufted-ear marmoset) | His | Full L. Full Length of Mature Protein (160-906) |
|
Involved Pathway
CDH2 involved in several pathways and played different roles in them. We selected most pathways CDH2 participated on our site, such as Adherens junctions interactions,Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDO in myogenesis | CDON,MYOD1,SPAG9,BNIP2,TCF4,TCF3A,CDH4,MYF6,CTNNA1,BOC |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSP,ACTN2,CTNNA2,LAMA2,CTNNA3,CACNG2,ITGB6,CACNG8,DMD,RYR2 |
| Cell adhesion molecules (CAMs) | NLGN4A,MHC2A,CD58,ITGA8,F11R,NTNG1,NLGN2B,ITGA4,CDH15,CLDN20 |
| Cell-Cell communication | CD151,CDH24,KIRRELB,CADM2B,CDH3,KIRREL3L,CDH12,CDH12A,NPHS1,COL17A1A |
| Cell junction organization | PARVB,CDH5,CDH13,CLDN3,CDH3,COL17A1,CDH10A,CDH12,COL17A1A,CADM2 |
| BDNF signaling pathway | SYN1,CNR1,CDKL5,EGR1,GRIP1,GNB2L1,EIF4E,DOK5,LINGO1,SIRPA |
| Arrhythmogenic right ventricular cardiomyopathy | CACNG3,CTNNA2,DSP,DSC2,DSG2,DES,DAG1,JUP,CACNG2,DMD |
| Adherens junctions interactions | JUP,CDH10A,PVRL1A,CDH8,PVRL2L,CTNNB1,ANG,CDH9,CDH12A,CDH3 |
Protein Function
CDH2 has several biochemical functions, for example, alpha-catenin binding,beta-catenin binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH2 itself. We selected most functions CDH2 had, and list some proteins which have the same functions with CDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GSTP1,FANCB,ETL4,ATMIN,ADARB1,GABRG2,CCDC123,ARMC2,SPOPL,GTF2A1 |
| gamma-catenin binding | PTPRJ,CTNNA1,PTPRK,LEF1,PTBP3,FER,TCF7L2,Fert2,APC2,DSG1A |
| protein phosphatase binding | DLG4,ITGA1,KAT2A,CTNNB1,MET,NEK2,DRD1A,PPP1R3C,PPP1R3G,CSF1R |
| protein kinase binding | GATA6,CCND3,CCNB3,CHRNA7,IL12RB2,BORA,JIP1,SHC3,ACTA2,CNPPD1 |
| calcium ion binding | EFCAB2,EHD3,THBS4B,OIT3,NCALD,ITSN2,SYT11A,NOTCH2,SYT16,CABP5 |
| beta-catenin binding | CDH1,TCF7,DACT1,GRIP1,KDM6B,CTNNA1,TBL1XR1,CDH5,SMAD3,NUMB |
| protein complex binding | CPS1,SLC25A3,LRRC16A,PFKP,NDUFA8,LRP1,GNB2,Casp3,LRP2,SLC27A5 |
| alpha-catenin binding | CDH24,PKP3,JUP,PKP2,CTNNB1,JUB,NUMB,VCL,JUPA,AJUBA |
| nitric-oxide synthase binding | NOS1AP,DMD,SLC6A4,CALM2,CAV3,CAV1,DNM2,SNTA1,ATP2B4,CALM3 |
Interacting Protein
CDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH2.
CTNNB1;PTPRC;PTPRB;PTPRG;PTPN6;PTPN7;PTPN12;PTPRJ;PTPRR;PTPRK;PTPRO;PTPN22;CTNND1;PRKAR1A;JUP;EXOC5
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