CDC7
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Official Full Name
cell division cycle 7 homolog -
Overview
The initiation of DNA replication in mammalian cells is a highly coordinated process that ensures duplication of the genome only once per cell division cycle. Origins of replication are dispersed throughout the genome, and their activities are regulated v -
Synonyms
CDC7;cell division cycle 7 homolog (S. cerevisiae);CDC7 (cell division cycle 7, S. cerevisiae, homolog) like 1 , CDC7 cell division cycle 7 (S. cerevisiae) , CDC7L1, cell division cycle 7 (S. cerevisiae);cell division cycle 7-related protein kinase
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- Insect (sf21)
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CDC7 involved in several pathways and played different roles in them. We selected most pathways CDC7 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | KIF20A,CDT1,GSK3AA,KNTC1,POLD3,ENSA,ACTR1A,ORC6,SKP1,MAD2L2 |
Protein Function
CDC7 has several biochemical functions, for example, ATP binding,kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC7 itself. We selected most functions CDC7 had, and list some proteins which have the same functions with CDC7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRIM26,ANO6,AIPL1,ALOX15,CCNE1,EPOR,RBM41,KRAS,PSMC5,ING2 |
| protein kinase activity | PDPK1B,STK25A,NLK2,SCYL2,EPHA4,MAPKAPK2A,COL4A3BP,NEK2,TEK,MAPK12B |
| metal ion binding | KLK1B3,UPB1,ZFYVE21,CISD2,ACAN,ZNF224,ZNF43,COL27A1A,NTNG1,RNF216 |
| kinase activity | NME2B.1,CAMK2D1,PRKAR1AA,PPM1E,FAM20B,PDXKB,RPS6KAL,TPK1,NTRK3A,SPS2 |
| ATP binding | CCT7,CFTR,EPHA8,MYO6A,PAPOLA,MYO3B,CDK11B,KTI12,AARS,DDX51 |
| protein serine/threonine kinase activity | PBK,GSK3A,MAP3K12,DCLK1,ROCK2,ULK1,LRRK2,PKN2,RIPK1,HIPK3 |
Interacting Protein
CDC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC7.
MCMBP;ORC5;CDK4;MCM3;CDKN1A;CDKN2A;MCM2;MCM10;ORC6;CHAF1A;DBF4;GPT;CDK9;GRHPR
Resources
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References
- Hou, Y; Wang, HQ; et al. Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 138:2027-2034(2012).
- Charych, DH; Coyne, M; et al. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells. JOURNAL OF CELLULAR BIOCHEMISTRY 104:1075-1086(2008).
