CDC42BPA
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Official Full Name
CDC42 binding protein kinase alpha (DMPK-like) -
Overview
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. -
Synonyms
CDC42BPA;CDC42 binding protein kinase alpha (DMPK-like);CDC42 binding protein kinase alpha (DMPK like);serine/threonine-protein kinase MRCK alpha;FLJ23347;KIAA0451;MRCK;MRCKA;PK428;DKFZp686P1738;MGC189823;A930014J19Rik;CDC42 binding protein kinase alpha;CDC42 binding protein kinase alpha dmpk like;CDC42 binding protein kinase beta;CDC42-binding protein kinase alpha;DKFZp686L1738;DMPK like;DMPK-like alpha;MRCK alpha;MRCKA_HUMAN;Myotonic dystrophy kinase related CDC42 binding protein kinase alpha;Myotonic dystrophy kinase-related CDC42-binding kinase alpha;Myotonic dystrophy protein kinase-like alpha;OTTHUMP00000035727;OTTHUMP00000035728;OTTHUMP00000035729;OTTHUMP00000035730;RP5-1087E8.4;Ser thr protein kinase PK428;Ser thr protein kinase related to the myotonic dystrophy protein kinase;Serine/threonine protein kinase MRCK alpha;ser-thr protein kinase PK428;CDC42 binidng protein kinase beta;C
Recombinant Proteins
- Human
- Rat
- Chicken
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CDC42BPA involved in several pathways and played different roles in them. We selected most pathways CDC42BPA participated on our site, such as CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42BPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDC42 signaling events | ARPC4,PAK4,ARPC5,CTNNA1,TNK2,ARPC2,ARPC1B,EPS8,CFL1,ACTR3 |
Protein Function
CDC42BPA has several biochemical functions, for example, ATP binding,identical protein binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42BPA itself. We selected most functions CDC42BPA had, and list some proteins which have the same functions with CDC42BPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | Serpina1c,MAP3K11,MSANTD3,RIPK1,SEPHS1,FAS,PPP1R13L,Serpina1b,SNX8,RALYL |
| protein serine/threonine kinase activity | GRK1A,RIOK2,STK32C,NLK2,BMPR1BB,ZAK,MAPK13,CSNK1G3,NEK11,MAPK12B |
| magnesium ion binding | ADPRH,PPM1N,GLUL,DYRK2,RPS6KA2,NT5C1A,PKLR,PPM1BB,ENOSF1,PPA1B |
| ATP binding | SHPK,GCLC,CARKD,MB21D1,NARS,IKBKAP,LYN,MYLK2,DSTYK,UBE2D2 |
| protein binding | PDE2A,RNF13,ZSCAN21,KRTAP5-6,SP140,BCL2,ORAI1,POLR1C,PCOLCE,SUN2 |
Interacting Protein
CDC42BPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42BPA here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42BPA.
CDC42;MYL12A;RHOQ;o92972-pro_0000278742;SNAPIN;TAF1;CDC42BPB
Resources
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References
- Hu, ZB; Li, Z; et al. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. NATURE COMMUNICATIONS 5:-(2014).
- Balasenthil, S; Chen, NY; et al. A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma. CANCER PREVENTION RESEARCH 4:137-149(2011).
