CASP1
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Official Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence -
Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. -
Synonyms
CASP 1;CASP-1;CASP1;CASP1_HUMAN;Caspase 1 apoptosis related cysteine peptidase;Caspase 1 apoptosis related cysteine protease;Caspase-1 subunit p10;Caspase1;ICE;IL 1 beta converting enzyme;IL 1BC;IL-1 beta-converting enzyme;IL-1BC;IL1 beta converting enzyme;IL1B convertase;IL1BC;IL1BCE;Interleukin 1 beta convertase;Interleukin 1 beta convertase precursor;Interleukin 1 beta converting enzyme;Interleukin 1B converting enzyme;Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;P45;OTTHUMP00000045728;OTTHUMP00000232029;OTTHUMP00000232030;OTTHUMP00000232031;OTTHUMP00000232032;OTTHUMP00000232033;OTTHUMP00000232034;OTTHUMP00000232036
Recombinant Proteins
- Human
- Mouse
- Rat
- Pig
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- HA
- His&Myc
Involved Pathway
CASP1 involved in several pathways and played different roles in them. We selected most pathways CASP1 participated on our site, such as NOD-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | GRIN1,NEFL,TNFRSF1A,SOD1,TP53,TRP53,NEFM,PPP3R1,ALS2,GRIA1 |
| Salmonella infection | RILP,PKN3,RELA,TLR4,MAPK3,IL8L1,MAPK14A,IL18,FLNB,RAB7A |
| Pertussis | PYCARD,C4BPB,C1S,C4BP,TNF,CALM3,CASP7,MAPK8,GM5077,C4A |
| Legionellosis | HSPA8,RELA,SAR1A,CXCL1,IL12B,Itgam&Itgb2,CR1,SAR1B,ITGB2L,NLRC4 |
| Influenza A | MAP2K7,HLA-DPA1,HSPA8,HLA-DRB3,DDX39B,HLA-DMA,CXCL8,TLR4,IKBKE,RAF1 |
| Cytosolic DNA-sensing pathway | IFNPHI3,IFNA12,POLR3B,IFNB,IKBKE,RELA,MB21D1,NFKBIAA,POLR3H,Ifna11 |
| NOD-like receptor signaling pathway | MAPK14B,NLRC4,HSP90AB1,CASP8,NAIP1,PSTPIP1A,PYCARD,MAP3K7,NFKBIB,BIRC3 |
Protein Function
CASP1 has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process,cysteine-type endopeptidase activity,NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP1 itself. We selected most functions CASP1 had, and list some proteins which have the same functions with CASP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activator activity involved in apoptotic process | BAD,PYCARD,NLRP12,BCL2L13,RPS27L,APAF1,CTSH,NOD1,CARD8,MAPK9 |
| NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP4,CASPB,CASP5,CASP12,PSD,CASPBL,CASPA |
| cysteine-type endopeptidase activity | USP10,CASPC,USP44,MALT1A,CTSF,USP49,USP31,USP51,USP24,CTSBB |
| protein binding | CENPJ,EXO1,KIF14,CENPK,OLFM4,CDK9,SCAMP1,POLG2,STRAP,SERP2 |
| endopeptidase activity | KLK1B3,PSMB2,PSMA6,PSMB5,PSMA7,SENP1,P4HB,F9,ATG4B,ACE |
Interacting Protein
CASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP1.
NLRC4;PYCARD;VAC14;IL1A;AIM2;ATG16L1;RIPK2
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References
- He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).
- Hoque, R; Farooq, A; et al. Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity. GASTROENTEROLOGY 146:1763-1774(2014).
