CAPN1
-
Official Full Name
calpain 1, (mu/I) large subunit -
Overview
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] -
Synonyms
CAPN1;calpain 1, (mu/I) large subunit;CANP;muCL;CANP1;CANPL1;muCANP;calpain-1 catalytic subunit;CANP 1;calpain mu-type;micromolar-calpain;calpain-1 large subunit;calpain, large polypeptide L1;calcium-activated neutral proteinase 1;cell proliferation-inducing protein 30;cell proliferation-inducing gene 30 protein
Recombinant Proteins
- Human
- Pig
- Rat
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- porcine erythrocytes
- Human Erythrocyte
- Porcine Erythrocytes
- Human
- Wheat Germ
- Mammalian Cell
- HEK293
- GST
- Non
- His
- His&Fc&Avi
Involved Pathway
CAPN1 involved in several pathways and played different roles in them. We selected most pathways CAPN1 participated on our site, such as Protein processing in endoplasmic reticulum,Apoptosis,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | PLCB3,NDUFC2,NDUFAB1,NDUFB10,ATP5G1,BAD,MME,CALM1,NDUFB5,Atp5g2 |
| Protein processing in endoplasmic reticulum | CCDC102A,TRAM1,UBE2D1B,HSPA1A,SELS,FBXO2,BCAP31,SKP1,PLAA,UBE2D2L |
| Apoptosis | GZME,IL1B2,PPP3R1B,STK24A,CAPN2L,NGF,TP53,NFKBIAA,IKBKG,H1F0 |
Protein Function
CAPN1 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity,cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN1 itself. We selected most functions CAPN1 had, and list some proteins which have the same functions with CAPN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal protein binding | FLNC,EPB41L3A,ALDOA,EPB41B,TNNT2A,ANXA2B,PTPN3,EPB41L5,DYNLL2,PACSIN2 |
| calcium-dependent cysteine-type endopeptidase activity | CAPN2A,CAPN1B,CAPN5A,CAPN2,CAPN3B,SOLH,CAPN2B,CAPN3A,SRI,CAPN2L |
| protein binding | RPL27A,KCNE4,IPO11,TDRD9,TAF12,AMIGO2,LRRC4B,ACE,GNA12,MAD2L1BP |
| calcium ion binding | F7,LTBP3,UMODL1,CDH13,NCALDA,PLS3,SCUBE1,EPS15,CCDC167,PPP3R1 |
Interacting Protein
CAPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN1.
PTPN1;CAPNS1;STAT3;EZR;RCAN1;TIRAP;F2R;GRIN2B;CLEC4G;ANKRD17;KATNA1;env
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