Bace2
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Official Full Name
beta-site APP-cleaving enzyme 2 -
Overview
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimers disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] -
Synonyms
BACE2;beta-site APP-cleaving enzyme 2;ASP1;BAE2;DRAP;AEPLC;ALP56;ASP21;CDA13;CEAP1;beta-secretase 2;memapsin-1;theta-secretase;aspartyl protease 1;56 kDa aspartic-like protease;Down syndrome region aspartic protease;transmembrane aspartic proteinase Asp1;membrane-associated aspartic protease 1;beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian cells
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Human Cell
- HEK293T
- Mamanlian cells
- GST
- His
- HIS
- His&GST
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
Bace2 involved in several pathways and played different roles in them. We selected most pathways Bace2 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bace2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | NDUFA3,GRIN1,APH1B,CYCS,NDUFA9,ATP5G1,UQCRFS1,NDUFA5,COX6A2,NDUFC2-KCTD14 |
Protein Function
Bace2 has several biochemical functions, for example, aspartic-type endopeptidase activity,beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bace2 itself. We selected most functions Bace2 had, and list some proteins which have the same functions with Bace2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aspartic-type endopeptidase activity | CTSD,SPPL2,NAPSA,ATP6AP2,CNTNAP5A,PGA,REN,PGA4,PSEN1,PIP |
| beta-amyloid binding | HBA-A2,NGFR,TM2D1,FBXO2,ITM2C,ARMCX5-GPRASP2,TSSK1B,APBA3,APBB3,BACE1 |
Interacting Protein
Bace2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bace2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Bace2.
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