BRAF
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Official Full Name
v-raf murine sarcoma viral oncogene homolog B1 -
Overview
The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three -
Synonyms
BRAF;v-raf murine sarcoma viral oncogene homolog B1;serine/threonine-protein kinase B-raf;BRAF1;p94;94 kDa B-raf protein;proto-oncogene B-Raf;murine sarcoma viral (v-raf) oncogene homolog B1;B-Raf proto-oncogene serine/threonine-protein kinase (p9
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- HEK293
- Sf9 Insect Cell
- Wheat Germ
- Insects cell
- Insect Cell
- Sf9 insect cell
- Mammalian Cell
- Sf21 Insect Cell
- Baculovirus-Insect cells
- E.coli
- Insect cells
- Protein Conjugation
- HEK293T
- Myc&DDK
- His&GST
- GST
- His&Flag
- His
- Flag
- Non
- His&Fc&Avi
Involved Pathway
BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | CRHR1,PLA2G4F,MAPK1,GNAS,ITPR1,GRIA2,PRKCA,PLCB1,IGF1,GNAZ |
| Bladder cancer | DAPK2,UPK3A,FGFR3,MMP2,MAPK3,CCND1,ERBB2,RB1,MAPK1,NRAS |
| Endometrial cancer | PIK3R2,AXIN2,PIK3CD,MAPK1,FOXO3,PIK3R1,AKT2,ARAF,RAF1,GRB2 |
| Rap signaling pathway | FGF13,NRAS,Adcy4,MAP2K3,FGF6,FGFR4,Itgam&Itgb2,RAP1GAP,RHOA,MAPK12 |
| Serotonergic synapse | GNAI1,PRKACG,CYP2C39,TPH1,ARAF,GNG8,HTR5A,PLCB4,GNAS,GNB1 |
| Pancreatic cancer | SMAD2,MAPK8,IKBKB,TP53,PIK3R5,TGFBR1,RAF1,RELA,KRAS,AKT2 |
| Natural killer cell mediated cytotoxicity | IFNGR2,SHC3,ITGB2L,MAP2K1,MAPK3,IFNA14,IFNAR2,FASLG,ULBP2,KLRC2 |
| Chronic myeloid leukemia | GAB2,RELA,CBLB,IKBKB,TGFBR1,CDK6,MECOM,PIK3R3,MAP2K2,PIK3CG |
| Colorectal cancer | APPL1,APC,APC2,MAPK8,ARAF,BIRC5,MAPK10,MSH3,MAP2K1,LEF1 |
Protein Function
BRAF has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase kinase kinase activity | MAP3K1,MAP3K13,KIAA1804,TAOK2,YSK4,ALPK2,MAP3K4,MAP3K5,MAP3K6,MAP3K3 |
| NOT small GTPase binding | RAF1 |
| protein kinase activity | AKT3A,RPS6KB1B,EPHA2A,MAP2K5,GUCY2F,PKN2,MAP3K3,LIMK1,LMTK2,EPHB2B |
| protein serine/threonine kinase activity | BSK146,MLKL,TESK2,MYO3A,EIF2AK2,CIT,SLK,MAPK13,NEK7,CPNE3 |
| protein binding | NEDD4,APBA3,ELP3,PPP2R3C,SSNA1,BLCAP,HYAL2,RNF6,GTF2B,Fert2 |
| ATP binding | DHX16,MAP3K10,MCM9,PFKM,CLCN3,EPRS,PARS2,LIMK2,PIK3CG,UBE2D4 |
| mitogen-activated protein kinase kinase binding | MAP3K11,IGBP1,MAPK8IP3,PIN1,TRIB3,TRIB2,ARRB1,ACE,TRIB1,KSR1 |
| calcium ion binding | PCDH2AB1,PCDH1GB9,RASGRP1,SLC25A25B,KCNIP2,CALML3,S100A5,CAPNS1B,HEG,EMR3 |
| identical protein binding | RUVBL2,PON2,PPP5C,ZBTB16,AKT1,PAK2,CEP72,PDGFB,LCK,ORAI1 |
Interacting Protein
BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1
Resources
Research Area
Cancer Drug TargetsIntracellular Kinases in the Akt Pathway
ROS and Stress Resistance
MAP3K
Glioma Biomarkers
Ovarian Cancer Biomarkers
Pancreatic Cancer Biomarkers
Oncoprotein-Signal Transducers
RAS-MAPK Pathway
Related Services
Related Products
References
- Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
- Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).
Reviews
Q&As
This protein is not a living modified organism, so it does not apply to the Cartagena Law in Japan. No worries.