BMF
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Official Full Name
Bcl2 modifying factor -
Overview
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
BMF;Bcl2 modifying factor;bcl-2-modifying factor
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- T7
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BMF involved in several pathways and played different roles in them. We selected most pathways BMF participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | DNMT1,PIK3R2,IKBKB,DICER1,TNXB,PTGS2,PLCG1,MMP9,CDC25B,TP53 |
Protein Function
BMF has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMF itself. We selected most functions BMF had, and list some proteins which have the same functions with BMF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PSMC2,HSPB9,FGF1,FAM86A,ATP5O,FAM212A,MYBPC1,FFAR2,FAM168A,PRKD2 |
Interacting Protein
BMF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMF here. Most of them are supplied by our site. Hope this information will be useful for your research of BMF.
REL;BCL2L1;BCL2L2;DYNLL2;TFIP11;SEC14L4
Resources
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References
- Zhu, LM; Cheng, XJ; et al. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. CANCER LETTERS 343:80-89(2014).
- Mansha, M; Wasim, M; et al. Problems encountered in bicistronic IRES-GFP expression vectors employed in functional analyses of GC-induced genes. MOLECULAR BIOLOGY REPORTS 39:10227-10234(2012).
