BECN1
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Official Full Name
beclin 1, autophagy related -
Overview
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration -
Synonyms
BECN1;beclin 1, autophagy related;ATG6;VPS30;beclin1;beclin 1 (coiled-coil, moesin-like BCL2 interacting protein);ATG6 autophagy related 6 homolog (S. cerevisiae);Beclin-1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197;GT197;ATG6 autophagy related 6 homolog;ATG6;VPS30;beclin1;Bcl-2-interacting protein beclin
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- GST
- His
- His&MBP
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
BECN1 involved in several pathways and played different roles in them. We selected most pathways BECN1 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with BECN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | IFNPHI3,INS2,IFNA13,Ifna11,IFNA12,ATG16L1,PRKAA1,PIK3R4,IFNA3,ULK3 |
Protein Function
BECN1 has several biochemical functions, for example, phosphatidylinositol 3-kinase binding,protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BECN1 itself. We selected most functions BECN1 had, and list some proteins which have the same functions with BECN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol 3-kinase binding | TYRO3,INSRR,IRS1,CALM2,IRS4,FYN,IGF1RA,CALM3,JAK2,INSR |
| protein binding | CTSL1,RPGRIP1,ANXA2,COPRS,TMEM120B,HOMER3,CDC5L,NLRX1,CLASP1,RGS7BP |
| ubiquitin protein ligase binding | UBOX5,EGFR,DTX1,UBE2K,BAG5,TRAF5,CALR,NKD2,YWHAZ,CUL9 |
Interacting Protein
BECN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BECN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BECN1.
ATG14
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