BCL2L11
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Official Full Name
BCL2-like 11 (apoptosis facilitator) -
Overview
Bim (bcl-2-interacting mediator of cell death) is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in regulating the intrinsic mitochondrial apoptotic pathway by inducing cytochrome c release, which in turn, activates caspase-9 and then caspase-3. Bim also plays a critical role in central and peripheral deletion of T lymphocytes and in controlling B cell homeostasis and activation. BimEL, the long isoform of Bim, is a ~28 kDa protein that is predominantly expressed in T and B cells and is activated by ERK1/2 pathway. The activation of BimEL by ERK1/2 promotes its phosphorylation on serine 65 (serine 69 in human), targeting it for degradation via the proteasome. -
Synonyms
BCL2L11;BCL2-like 11 (apoptosis facilitator);bcl-2-like protein 11;bcl2-L-11;Bcl2 interacting mediator of cell death;bcl2-interacting mediator of cell death;Bim;Bod;1500006F24Rik
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Wheat Germ
- E.coli
- Yeast
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
BCL2L11 involved in several pathways and played different roles in them. We selected most pathways BCL2L11 participated on our site, such as Activation of BH3-only proteins,Activation of BIM and translocation to mitochondria,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | ECT2,ARHGAP4A,ITSN1,ARHGEF18,ARHGEF3,FGD4A,KALRNB,TRIO,TIAM2,ARHGEF9 |
| B Cell Receptor Signaling Pathway | PPP3CB,PPP3R1,PIK3CB,PILRB,PDK2B,INPP5D,PLEKHA2,PDPK1A,ARPC4,CR2 |
| BDNF signaling pathway | GRIP1,CSNK2A1P,DPYSL2,MAP3K2,KCNN2,CDKL5,CDK5,CFL1,GNB2L1,CNR1 |
| Apoptosis | PPP3CC,PANK1A,PPP3R1B,MYD88,BAXA,DAPK1,CRADD,CASP9,HIST1H1D,PRKACAB |
| Apoptosis Modulation and Signaling | PTPN13,CAPNS1,HRK,DAXX,CASP2,BOK,BIK,DIABLO,BAG3,DFFA |
| Activation of BH3-only proteins | YWHAQ,CDK5RAP2,AKT3,E2F1,DYNLL2 |
Protein Function
BCL2L11 has several biochemical functions, for example, contributes_to microtubule binding,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L11 itself. We selected most functions BCL2L11 had, and list some proteins which have the same functions with BCL2L11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PSMC3,STAU2,PITX2,VPS37A,MKRN2,HIST1H4A,GAB2,SLC9A7,MORN4,ITGB1BP2 |
| microtubule binding | CCDC87,JAKMIP3,KIF2B,NME8,KIF1C,KIF17,CRYAB,SYBU,NUMA1,KIF27 |
Interacting Protein
BCL2L11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L11 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L11.
MCL1;BCL2L1
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