BATF3
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Official Full Name
basic leucine zipper transcription factor, ATF-like 3 -
Overview
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription. -
Synonyms
BATF3;basic leucine zipper transcription factor, ATF-like 3;basic leucine zipper transcriptional factor ATF-like 3;JDP1;Jun dimerization protein 1;JUNDM1;SNFT;21 kDa small nuclear factor isolated from T-cells;ATF like 3;B-ATF-3;FLJ36352;FLJ37535;hCG 39202;Jun dimerization protein p21SNFT;21-kD small nuclear factor isolated from T cells
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- Mammalian Cell
- E.coli
- Mammalian cells
- Yeast
- HEK293T
- HEK293
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BATF3 involved in several pathways and played different roles in them. We selected most pathways BATF3 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Calcium signaling in the CD4+ TCR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BATF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | DGKA,IRF4,EGR2,JUNB,CDK4,EGR4,IKZF1,EGR1,EGR3,CTLA4 |
| Calcium signaling in the CD4+ TCR pathway | RCAN1,POU2F1,CSF2,AKAP5,FKBP1A,JUNB,RCAN2,CHP |
Protein Function
BATF3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BATF3 itself. We selected most functions BATF3 had, and list some proteins which have the same functions with BATF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | SKOR2,PROX1,C1QBP,SOD3,CIR1,CSDA,ZHX2,BCOR,JUB,NR0B2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | KCNA3,KLF13,DLX4,CEBPB,SP1,ZGPAT,FOXK2,FOXL2,TFAP2A,TFE3 |
| protein binding | UNC119B,FAM115A,HOXB9,USP36,KAT8,FUBP3,DPH1,DCTN4,EIF3C,RNF24 |
| transcription factor activity, sequence-specific DNA binding | HOXD4,FOXP1B,GLI3,LEF1,TAF13,DMRT3A,DRAP1,WT1,PHF5A,NR2F5 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NR2C1,ATF3,GFI1,ZKSCAN3,MYPOP,PRDM5,NFATC2,OVOL1,ESRRA,TBX3 |
Interacting Protein
BATF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BATF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BATF3.
DDIT3;APPL1;CREB3;JUN;ATF2;JUNB;JUND;CEBPB;ATF3;DDIT3;CEBPD;CEBPG
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References
- Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
- Alfaro, C; Onate, C; et al. Specialized dendritic cells in cross-presentation of exogenous antigens to cytotoxic T lymphocytes. ANALES DEL SISTEMA SANITARIO DE NAVARRA 36:519-537(2013).
