ATP6V1E1
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Official Full Name
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. -
Synonyms
ATP6V1E1;ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1;ATP6E, ATP6V1E, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD , ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1;V-type proton ATPase subunit E 1;ATP6E2;P31;Vma4;ATP6E;ATP6V1E;V ATPase 31 kDa subunit;Vacuolar proton pump subunit E 1;OTTHUMP00000065606;OTTHUMP00000196213;OTTHUMP00000214152;OTTHUMP00000214153;V-ATPase, subunit E;V-ATPase subunit E 1;V-ATPase 31 kDa subunit;H+-transporting ATP synthase chain E, vacuolar;H(+)-transporting two-sector ATPase, 31kDa subunit
Recombinant Proteins
- Human
- Chicken
- Mouse
- Cynomolgus
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ATP6V1E1 involved in several pathways and played different roles in them. We selected most pathways ATP6V1E1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ITGB3B,TLR2,NCF1,ATP6V0E1,SEC61G,Pla2r1,NOX1,TUBA3E,BLB1,HLA-DRB5 |
| Metabolic pathways | UGT1A1,ATP5C1,SC4MOL,TSTA3,TWISTNB,ACSL5,DHCR7,ST6GALNAC6,ALDH9A1A.1,HGSNAT |
| Epithelial cell signaling in Helicobacter pylori infection | IKBKG,NFKB1,MAP3K14,IKBKB,JAM2,RELA,NOD1,ATP6V1A,CDC42,MAPK12 |
| Synaptic vesicle cycle | SLC18A2,STXBP1,ATP6V0E2,ATP6V1G2,ATP6V0A4,DNM3,ATP6V1D,ATP6V0B,UNC13C,CPLX3 |
| Oxidative phosphorylation | NDUFS3,NDUFA5,SDHD,ctaG,NDUFB3,PPA1A,COX5B2,NDUFB7,NDUFB6,ATP6V0A1B |
| Rheumatoid arthritis | CXCL12,CD80,ATP6V1H,H2-AA,ATP6V0A1,IL1A,CCL5,ATP6V0D1,HLA-DOA,ATP6AP1 |
| Collecting duct acid secretion | CLCNKB,ATP6V1B1,ATP6V0C,ATP6V0D2,ATP6V0E1,ATP6V0E,TCIRG1,ATP6V1G3,ATP6V1B2,ATP6V0A2 |
| Vibrio cholerae infection | KDELR1,ATP6V1B2,PRKACG,PRKACB,PLCG1,ATP6V0D2,ERO1L,PRKACA,ATP6V1F,KDELR2 |
Protein Function
ATP6V1E1 has several biochemical functions, for example, ATPase binding,hydrogen-exporting ATPase activity, phosphorylative mechanism,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1E1 itself. We selected most functions ATP6V1E1 had, and list some proteins which have the same functions with ATP6V1E1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proton-transporting ATPase activity, rotational mechanism | ATP6V0E2,TCIRG1,ATP6V0A1A,ATP5E,ATP6V1C1,ATPV0E2,ATP6V0CA,ATP6AP1B,ATP6V1H,ATP6V1AA |
| hydrogen-exporting ATPase activity, phosphorylative mechanism | ATP6V1G1,ATP6V1G3,ATP6V1E2,ATP6V0D1,ATP6V1C2,ATP6V1C1 |
| protein binding | GSS,HYPK,KCNIP3,WBP2NL,LAPTM4B,EIF1AY,CCND1,C1orf50,ZBTB8A,SKIV2L2 |
| ATPase binding | GRIN2A,ZNHIT6,SNX10,ATXN3,ATPIF1,FAM119A,ATPIF1B,FXYD7,SVIP,TOR1AIP2 |
Interacting Protein
ATP6V1E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1E1.
DEDD;ATP6V1G1;ATP6V1G2;XRCC6;MESDC2;pyrH;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;ATP6V1A;Rmdn3;Chmp4b;CHMP4B;GOLT1B
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References
- Yang, LS; Xu, XE; et al. iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p. JOURNAL OF PROTEOMICS 77:480-491(2012).
- Knijnenburg, J; van Bever, Y; et al. A 600 kb triplication in the cat eye syndrome critical region causes anorectal, renal and preauricular anomalies in a three-generation family. EUROPEAN JOURNAL OF HUMAN GENETICS 20:986-989(2012).
