ARRB1
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Official Full Name
arrestin, beta 1 -
Overview
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011] -
Synonyms
ARRB1;arrestin, beta 1;ARB1;ARR1;beta-arrestin-1;arrestin 2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Rabbit
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mamanlian cells
- HEK293T
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ARRB1 involved in several pathways and played different roles in them. We selected most pathways ARRB1 participated on our site, such as MAPK signaling pathway,Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | ARR3B,JIP1,CACNB2A,ACVR1C,MAP3K12,MAPK12B,RAP1A,STMN1B,GADD45BA,FGFR4 |
| Endocytosis | EHD2,ARFGAP3,ARFGAP2,WASH,SPG20A,GRK4,KIF5B,RAB11FIP1,ARF6,FAM21C |
| Chemokine signaling pathway | CXCR6,CCL25,GNG12,GSK3B,MAPK1,NRAS,Ccl12,PIK3R3,CCR7,PARD3 |
| Olfactory transduction | PRKACB,OLFR49,RGS2,PDE2A,OLFR15,OR1L1,OLFR154,OR2H1,OLFR495,OLFR1038-PS |
Protein Function
ARRB1 has several biochemical functions, for example, AP-2 adaptor complex binding,GTPase activator activity,alpha-1A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARRB1 itself. We selected most functions ARRB1 had, and list some proteins which have the same functions with ARRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | NKX3-1,SMAD2,DDX3X,BCOR,SNF8,PPP1R13B,GCM1,PITX2,THRA,PARP1 |
| insulin-like growth factor receptor binding | INSR,INSL4,GNAS,SOCS1,IGF2A,IGF1,SOCS2,SHC1,YWHAH,IGF2B |
| transcription regulatory region DNA binding | ZNF217,ZNF613,ZNF335,EGR2,JUN,RREB1,MESP1,NCOR1,TBL1XR1,TFAP4 |
| angiotensin receptor binding | DRD1,ARRB2,DRD1A |
| alpha-1B adrenergic receptor binding | ADRA2A,ARRB2 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | MT3,GAS6,C1QL4L,BIRC2,AVP,CD27,DPEP1,VIL1,TFAP2B,PRDX3 |
| protein phosphorylated amino acid binding | BTRC,CRK |
| ubiquitin protein ligase binding | SLC22A18,PML,ACVR1B,DBT,RFFL,AXIN1,TRIM28,UBE2N,DAXX,GABARAPL1 |
| follicle-stimulating hormone receptor binding | ARRB2 |
Interacting Protein
ARRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARRB1.
MAPK9;GNMT;ARRB2;ZRANB2
ARRB1 Related Signal Pathway
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References
- Sakai, H; Matsuura, K; et al. Signaling Mechanism Underlying the Promotion of Keratinocyte Migration by Angiotensin II. MOLECULAR PHARMACOLOGY 87:277-285(2015).
- Campo, GM; Avenoso, A; et al. Beta-arrestin-2 negatively modulates inflammation response in mouse chondrocytes induced by 4-mer hyaluronan oligosaccharide. MOLECULAR AND CELLULAR BIOCHEMISTRY 399:201-208(2015).
