ARID1A
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Official Full Name
AT rich interactive domain 1A (SWI-like) -
Overview
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
ARID1A;AT rich interactive domain 1A (SWI-like);ELD;B120;OSA1;P270;hELD;BM029;MRD14;hOSA1;BAF250;C1orf4;BAF250a;SMARCF1;AT-rich interactive domain-containing protein 1A;osa homolog 1;SWI-like protein;brain protein 120;OSA1 nuclear protein;BRG1-associated factor 250a;SWI/SNF complex protein p270;chromatin remodeling factor p250;ARID domain-containing protein 1A;SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Insect Cell
- E.coli
- HEK293
- His
- GST
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARID1A-1909M | Recombinant Mouse ARID1A Protein | Mammalian Cell | Mouse | His |
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| Arid1a-3676M | Recombinant Mouse Arid1a, His-tagged | E.Coli or Yeast | Mouse | His | 2283 |
|
| ARID1A-3677H | Recombinant Human ARID1A, His-tagged | E.Coli or Yeast | Human | His | 2285 |
|
| ARID1A-792H | Recombinant Human ARID1A protein, GST-tagged | Wheat Germ | Human | GST |
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| ARID1A-2201H | Recombinant Human ARID1A protein, His&Myc-tagged | Insect Cell | Human | His&Myc | 1976-2231aa |
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| ARID1A-2488H | Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged | E.coli | Human | His&Myc | 1976-2231 aa |
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| ARID1A-2549H | Recombinant Human ARID1A protein, His&Myc-tagged | E.coli | Human | His&Myc | 1976-2231aa |
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| ARID1A-2751H | Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged | Insect Cell | Human | His&Myc | 1976-2231 aa |
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| ARID1A-705M | Recombinant Mouse ARID1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ARID1A-705M-B | Recombinant Mouse ARID1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARID1A involved in several pathways and played different roles in them. We selected most pathways ARID1A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Prostate Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostate Cancer | PIK3CB,AKT2,PIK3R5,SMARCA4,Pdgfa&Pdgfb,INS,PDGFB,INS2,FGFR1,MDM2 |
| Chromatin organization | KAT6A,PRMT6,PADI3,KAT6B,C20orf20,DNMT3A,PADI6,ING5,AEBP2,WDR77 |
| Chromatin modifying enzymes | PADI2,SMARCC1,ING5B,ATXN7L3,MBD3,BRPF3,ANO9A,MTA1,KDM4D,SMARCC1B |
| RMTs methylate histone arginines | SMARCD3B,ARID2,SMARCE1,SMARCC2,PRMT6,SMARCB1,WDR77,SMARCA2,SMARCD1,SMARCB1B |
Protein Function
ARID1A has several biochemical functions, for example, DNA binding,ligand-dependent nuclear receptor binding,nucleosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID1A itself. We selected most functions ARID1A had, and list some proteins which have the same functions with ARID1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SOX19A,EPAS1,ASXL2,RPL7,NFATC2,PPARD,ZBTB42,FOXL2,EXO5,FOXJ1 |
| nucleosome binding | RNF169,DNTTIP1,HP1BP3,NOC2L,RNF168,MUM1,ZNHIT1,L3MBTL1,RNF4,SMARCA5 |
| ligand-dependent nuclear receptor binding | PPARGC1A,PROX1,TADA3,C1D,NCOR2,NCOA2,SMARCD3,SMARCE1,UBA3,MED1 |
| transcription coactivator activity | RFXAP,SETD3,SP100,ATF6,FHL5,SMARCA4,THRAP3,CCNE1,POU2AF1,BRD7 |
| protein binding | NRAP,METTL13,NCDN,MYBPHL,PKD1L3,VPS24,STAC,RBKS,S100A2,FBLIM1 |
Interacting Protein
ARID1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID1A.
SMARCA4
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References
- Yoneyama, K; Kojima, S; et al. Proteomic Identification of Autoantibodies in Sera from Patients with Ovarian Cancer as Possible Diagnostic Biomarkers. ANTICANCER RESEARCH 35:881-889(2015).
- Yamamoto, H; Watanabe, Y; et al. An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa. WORLD JOURNAL OF GASTROENTEROLOGY 20:3927-3937(2014).
