APOC2
-
Official Full Name
apolipoprotein C-II -
Overview
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011] -
Synonyms
APOC2;apolipoprotein C-II;APO-CII;APOC-II;apolipoprotein C2
Recombinant Proteins
- Mouse
- Horse
- Guinea pig
- Cynomolgus
- Rhesus macaque
- Human
- Rat
- Mammalian Cells
- E.coli
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Human Plasma
- His
- His&T7
- His&GST
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
APOC2 involved in several pathways and played different roles in them. We selected most pathways APOC2 participated on our site, such as Chylomicron-mediated lipid transport,HDL-mediated lipid transport,Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | LPAR2B,OPN4.1,RARG,RXFP2B,CXCL11.8,NCKIPSD,PCSK6,RDH13,GMIP,LRP12 |
| Retinoid metabolism and transport | RBP1,AKR1C21,LRP10,AKR1C6,BCO2A,CLPS,APOA4B.2,BCO2L,APOM,RBP2A |
| Metabolism | SLC25A32,GLS2B,SULT1B1,NDUFA11,ARSK,NUDT3,CYP27B1,SLC26A1,PEMT,SLC25A10 |
| Lipoprotein metabolism | Alb,CETP,MTP,APOF,LPA,APOA1B,APOA4A,APOA4B.2,APOA5,APOA4B.1 |
| HDL-mediated lipid transport | CETP,APOA1B,ABCA1,AMN,BMP1A,Alb |
| Metabolism of lipids and lipoproteins | DECR1,ACSF2,FAAH2,PLBD1,ACOT6,ACOT7,ARF3,MED7,MED23,CYP2N13 |
| Lipid digestion, mobilization, and transport | APOEA,APOBB.1,APOA4A,FABP1B.1,APOA4B.2,APOA1B,APOA4B.1,ABCA1,MTP,APOA5 |
| Chylomicron-mediated lipid transport | APOA4A,APOA5,MTP,APOA1B,APOA4B.2,APOA4B.1,APOEB,APOEA,APOBB.1 |
Protein Function
APOC2 has several biochemical functions, for example, lipase inhibitor activity,lipid binding,lipoprotein lipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC2 itself. We selected most functions APOC2 had, and list some proteins which have the same functions with APOC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipase activator activity | ARHGAP6,GM2A,CCL3,CCL5,CCL8,PDPK1 |
| protein homodimerization activity | OXA1L,HPGDS,FGFR2,GM5506,PDGFA,SMAD2,HSD17B4,CREB3,CHMP3,TCF3A |
| lipase inhibitor activity | APOA2,FAF2,APOC1,APOC3,APOA1 |
| phospholipase binding | CALM,ARHGAP6,CALM1,LMNB1,SERPINB1A,WAS,SELE,PRKCZ,CALM2,PARK2 |
| lipoprotein lipase activator activity | APOH,APOA5 |
| lipid binding | CRABP2A,GLTP,CADPS,Fert2,FABP11B,STARD7,APOA4,CYTH4,PACSIN1B,ANXA6 |
Interacting Protein
APOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC2.
d-mannose;APOE;APOA2;ALB;APOB
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