APC

  • Official Full Name

    adenomatous polyposis coli

  • Overview

    Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates beta-catenin via interactions with Axin/GSK3-beta complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.

  • Synonyms

    APC;adenomatous polyposis coli;adenomatosis polyposis coli;adenomatous polyposis coli protein;DP2;DP2.5;DP3;PPP1R46;protein phosphatase 1;regulatory subunit 46;deleted in polyposis 2.5;adenomatosis polyposis coli tumor suppressor;protein phosphatase 1, regulatory subunit 46;GS;BTPS2

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • Human Plasma
  • Wheat Germ
  • E.coli
  • E.Coli or Yeast
  • Mammalian Cell
  • HEK293
  • Non
  • GST
  • His
  • His&T7
  • His&SUMO
  • N-His&C-Myc
  • His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
APC-001H Active Native Human Activated Protein C Human Plasma Human Non
APC-12H Recombinant Human APC protein, GST-tagged Wheat Germ Human GST 2744-2843 a.a.
APC-27359TH Recombinant Human APC, His-tagged E.coli Human His 2687-2843 a.a.
Apc-3153R Recombinant Rat Apc, His-tagged E.Coli or Yeast Rat His 2842
APC-712R Recombinant Rat APC Protein Mammalian Cell Rat His
APC-7260Z Recombinant Zebrafish APC Mammalian Cell Zebrafish His
APC-90HCL Recombinant Human APC cell lysate Human Non
APC-01H Recombinant Human APC Protein, His-tagged E.coli Human His 955-1382 a.a.
APC-02H Recombinant Human APC protein, His-T7-tagged E.coli Human His&T7 Ala2634~Val2843
APC-1307H Recombinant Human APC Protein (L407-S751), Tag Free E.coli Human Non L407-S751
APC-1308H Recombinant Human APC Protein (L407-S751), His tagged E.coli Human His L407-S751
APC-200H Recombinant Human APC Protein, His-tagged E.coli Human His Thr2635-Val2843
Apc-201M Recombinant Mouse Apc Protein, His&SUMO-tagged E.coli Mouse His&SUMO Ala2529-Ser2841
Apc-202R Recombinant Rat Apc Protein, His-tagged E.coli Rat His Ile213-Lue461
APC-203H Recombinant Human APC Protein, His-tagged E.coli Human His Ala2634-Val2843
APC-3422H Recombinant Human APC protein, His&Myc-tagged E.coli Human N-His&C-Myc 960-1337aa
Apc-3633M Recombinant Mouse Apc protein, His&Myc-tagged E.coli Mouse His&Myc 958-1335a.a.
APC-368R Recombinant Rat APC Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
APC-368R-B Recombinant Rat APC Protein Pre-coupled Magnetic Beads HEK293 Rat
Apc-544M Recombinant Mouse Apc Protein, His-tagged E.coli Mouse His Ser2636~Val2845
Apc-545R Recombinant Rat Apc Protein, His-tagged E.coli Rat His Ala2634~Val2842

    Involved Pathway

    APC involved in several pathways and played different roles in them. We selected most pathways APC participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway FZD9,PLCB1,CAMK2G1,FBXW11B,WNT8B,MAPK8A,CAMK2A,RBX1,RAC3,PLCB4
    MicroRNAs in cancer STMN1,SLC7A1,HNRNPK,SOX4,CYP24A1,BMPR2,CDCA5,PIK3R2,ST14,GLS2
    Colorectal cancer MAPK3,ARAF,KRAS,MSH2,PIK3R1,MAPK1,CASP9,Casp3,MSH6,PIK3R5
    Regulation of Actin Cytoskeleton ITGB4,WAS,APC2,ITGA11A,FGF16,RHOA,CFL2L,ITGAL,PIP5K1C,RHOAD
    HTLV-I infection Adcy4,PIK3R2,HLA-DRB1,GM-CSF,SLC25A4,ATM,POLE2,MRAS,WNT7B,HLA-DOA
    Hippo signaling pathway PRKCZ,Fzd4,NF2,FGF1,WNT8A,SMAD3,PPP1CC,LEF1,WNT1,FZD5
    Pathways in cancer CBLB,FIGF,AXIN1,BCR,CCNE1,RET,GLI2,PLCB1,TRAF4,HHIP
    Signaling pathways regulating pluripotency of stem cells PIK3CB,ID3,MEIS1,FGFR2,AKT1,FZD7,HOXB1,WNT6,WNT1,ESRRB
    Endometrial cancer MAPK1,PTEN,PIK3R2,RAF1,PIK3R1,MAP2K1,PIK3R3,MAP2K2,FOXO3,BRAF

    Protein Function

    APC has several biochemical functions, for example, beta-catenin binding,NOT cadherin binding,gamma-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC itself. We selected most functions APC had, and list some proteins which have the same functions with APC. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase regulator activity CSNK2B,CDK5RAP1,KIDINS220B,CDC37,ANKRD54,FAF1,KIDINS220,RAC2
    microtubule plus-end binding DST,CLASP1,MAPRE1,CLASP1A,CLIP1,KIF2C,CLIP2,KIF18A,STIM1
    protein binding TRMT12,RPL36AL,C10orf33,TACR2,SNCA,G3BP2,KRTAP3-3,RGS8,MTERF,KLF17
    gamma-catenin binding FER,APC2,PTPRJ,DSG1,PTBP3,CTNNA1,LEF1,CDH2,PTPRK,TCF7L2
    microtubule binding KIF4,CLASP1,SPAST,KIF23,LRPPRC,NEFH,S100A9,MAP1LC3C,CEP57L1,NUMA1
    beta-catenin binding C,NF2,BCL9,CDH2,FAM123B,TCF7L1B,GSK3B,TBL1X,SLC9A3R2,CHD8
    protein kinase binding PTPRJ,FAM83D,GPRC5B,ACSL3,TCF7L2,RB1CC1,PDPK1,STAT3,PPP1R12C,TRIM22

    Interacting Protein

    APC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC here. Most of them are supplied by our site. Hope this information will be useful for your research of APC.

    CTNNB1;MAPRE1

    APC Related Signal Pathway

    Resources

    References

    • Fernandez, JA; Deguchi, H; et al. Re-Evaluation of the Anticoagulant Properties of High-Density Lipoprotein-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:570-572(2015).
    • Schouten, M; van't Veer, C; et al. The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis. THROMBOSIS RESEARCH 135:537-543(2015).

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