ANKHD1
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Official Full Name
ankyrin repeat and KH domain containing 1 -
Overview
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. -
Synonyms
ANKHD1;ankyrin repeat and KH domain containing 1;ankyrin repeat and KH domain-containing protein 1;FLJ10042;FLJ11979;FLJ14127;FLJ20288;KIAA1085;MASK;ANKH1_HUMAN;ANKHD 1;Ankyrin repeat and KH domain containing protein 1;HIV-1 Vpr-binding ankyrin repeat protein;HIV1 Vpr binding ankyrin repeat protein;hMASK;Multiple ankyrin repeats single KH domain;Multiple ankyrin repeats single KH domain homolog;PP2500;VBARP;OTTHUMP00000159883;OTTHUMP00000174758;OTTHUMP00000174759;OTTHUMP00000174760;multiple ankyrin repeats, single KH-domain homolog
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- HEK293T
- His
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANKHD1-9659H | Recombinant Human ANKHD1, His-tagged | E.coli | Human | His | C-term-350a.a. | |
| ANKHD1-4497C | Recombinant Chicken ANKHD1 | Mammalian Cell | Chicken | His |
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| ANKHD1-565H | Recombinant Human ANKHD1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ANKHD1-7881Z | Recombinant Zebrafish ANKHD1 | Mammalian Cell | Zebrafish | His |
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| ANKHD1-1214HF | Recombinant Full Length Human ANKHD1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 627 amino acids |
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| ANKHD1-155H | Recombinant Human ANKHD1 Protein, His-tagged | E.coli | Human | His | Val204-Ala563 |
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| ANKHD1-2073H | Recombinant Human ANKHD1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| ANKHD1-5946H | Recombinant Human ANKHD1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
ANKHD1 involved in several pathways and played different roles in them. We selected most pathways ANKHD1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ANKHD1 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKHD1 itself. We selected most functions ANKHD1 had, and list some proteins which have the same functions with ANKHD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | POLR2A,SRPK1,ARHGAP1,SIK2,DHRS2,IER3,KHDRBS2,CRP,SUMO1,EIF4E |
| poly(A) RNA binding | SCAF4,NGRN,TRIM56,U2SURP,SRSF2,COA6,RBM4B,YWHAZ,BRIX1,PTRH1 |
Interacting Protein
ANKHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKHD1.
NFKBIE;vpr;BAP1;SCHIP1;ATXN1;YWHAG;YWHAE;ZNF346;VCAM1;Unc93b1
Resources
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References
- Dhyani, A; Machado-Neto, JA; et al. ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth. EUROPEAN JOURNAL OF CANCER 51:252-259(2015).
- Rodrigues, P; Saad, S; et al. ANKYRIN REPEAT AND KH DOMAIN CONTAINING 1 (ANKHD1), A NEW SCAFFOLDING PROTEIN, REDUCES APOPTOSIS AND IS MODULATED IN LEUKEMIC CELLS. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:270-270(2010).
