ALOX5AP
-
Official Full Name
arachidonate 5-lipoxygenase-activating protein -
Overview
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] -
Synonyms
ALOX5AP;arachidonate 5-lipoxygenase-activating protein;FLAP;MK-886-binding protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Bovine
- Oryctolagus cuniculus (Rabbit)
- Macaca mulatta
- Sheep
- Sus scrofa (Pig)
- Mus musculus
- Macaca fascicularis
- Horse
- Insect Cells
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- Avi&His&Fc
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ALOX5AP involved in several pathways and played different roles in them. We selected most pathways ALOX5AP participated on our site, such as Arachidonic acid metabolism,Eicosanoid Synthesis,IL-5 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Eicosanoid Synthesis | PNPLA8,DPEP1 |
| Metabolism | APOA4B.2,CKMT2A,HELZ2,NDUFS7,NUDT11,CSNK1G2,NDUFAF7,UGT1B4,IP6K3,LYPLA1 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | PTGR1,DPEP2,ALOX5B.3,DPEP1,ALOX5B.2 |
| Synthesis of 5-eicosatetraenoic acids | ALOX5B.2,ALOX5B.3 |
| Arachidonic acid metabolism | CYP2B6,CYP2P9,CYP2J6,PLA2G2A,CYP2E1,CYP4B1,GPX1A,PTGS1,GPX7,PTGESL |
| Metabolism of lipids and lipoproteins | MED8,ACSF2,DPEP2,APOA4B.1,DGAT1B,CDIPT,DPEP1,SACM1LA,APOA4A,PMVK |
| IL-5 Signaling Pathway | UNC119,GSK3AB,SDCBP |
| Selenium Pathway | TXNRD2,SEP15,SAA2-SAA4,CRP,PRDX4,DIO2,TXNRD3IT1,SELT,SERPINA3,MSRB1 |
Protein Function
ALOX5AP has several biochemical functions, for example, arachidonic acid binding,enzyme activator activity,NOT glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5AP itself. We selected most functions ALOX5AP had, and list some proteins which have the same functions with ALOX5AP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | TAB1,CTSA,PPP1R12B,PRKCE,MMP15,DBF4,GLC8,PITRM1,MMP24,ASAP2 |
| arachidonic acid binding | CYP4F14,S100A9,CYP4A14,S100A8,PPARG,STX3 |
| NOT glutathione transferase activity | CLIC3,CLIC5,CLIC2,CLIC1 |
| protein binding | TTF2,FOXD3,LRP2,ATG16L1,FANCB,GNG4,SMO,HNRNPD,ZNF266,TMEM115 |
| protein N-terminus binding | EXOC4,SMARCA4,PEX19,TP53,KCNB1,EIF3E,PIAS3,NBN,RELA,ERCC4 |
Interacting Protein
ALOX5AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5AP here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5AP.
CLIC1
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