ALDH6A1
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Official Full Name
aldehyde dehydrogenase 6 family, member A1 -
Overview
This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. -
Synonyms
ALDH6A1;aldehyde dehydrogenase 6 family, member A1;MMSDH;methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial;malonate-semialdehyde dehydrogenase;aldehyde dehydrogenase family 6 member A1;mitochondrial acylating methylmalonate-semial
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ALDH6A1 involved in several pathways and played different roles in them. We selected most pathways ALDH6A1 participated on our site, such as Valine, leucine and isoleucine degradation,beta-Alanine metabolism,Inositol phosphate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | HMGCRB,TREH,ST8SIA1,NDUFA10,NOS2,MTHFD1L,UROS,AK8,COX5A,CYP27B1 |
| Valine, leucine and isoleucine degradation | BCAT1,AOX3,OXCT1A,BCKDHA,ACAT1,HADH,ALDH3A2,PCCA,ALDH9A1,PCCB |
| beta-Alanine metabolism | HADHAA,ALDH9A1A.1,ALDH2.2,GAD1B,ALDH1B1,ALDH1A3,AOC2,AOC3,ALDH9A1B,ALDH3B1 |
| Propanoate metabolism | ACAT2,PCCB,HIBCH,SUCLG2,HADHAA,ACACA,ACAT1,PCCA,BCKDHA,MLYCD |
| Inositol phosphate metabolism | MTM1,PIK3C2A,MTMR2,MINPP1,PLCD3,TPI1B,INPP4AB,NUDT10,INPP4A,PLCD4 |
| Carbon metabolism | GOT2B,PGLS,SHMT1,PKMB,TPI1A,DAK,FH,PGP,ME3,PKLR |
Protein Function
ALDH6A1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,fatty-acyl-CoA binding,malonate-semialdehyde dehydrogenase (acetylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH6A1 itself. We selected most functions ALDH6A1 had, and list some proteins which have the same functions with ALDH6A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | DDX55,TIAL1,HSPB1,SNRPD3,SYNE1,WBSCR22,SMNDC1,GLRX3,RSRC2,PRPF3 |
| aldehyde dehydrogenase (NAD) activity | ALDH2,ALDH4A1,ALDH16A1,ALDH1L1,ALDH3A2,ALDH3B2,ALDH5A1,ALDH9A1,Aldh1a7,ALDH9A1A.1 |
| fatty-acyl-CoA binding | ACBD5A,ACBD6,ACBD7,ACBD4,ACOXL,DBIL5,ACADS,ETFA,ACOX2,ACOT7 |
| thiolester hydrolase activity | ACOT5,UFSP2,PPT2,Acnat1,UFSP1,ACNAT2 |
Interacting Protein
ALDH6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH6A1.
TRMT10C;LMO2;NDUFS7
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