ALAS2
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Official Full Name
aminolevulinate, delta-, synthase 2 -
Overview
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ALAS2;aminolevulinate, delta-, synthase 2;aminolevulinate, delta , synthase 2 (sideroblastic/hypochromic anemia) , ASB;5-aminolevulinate synthase, erythroid-specific, mitochondrial;sideroblastic/hypochromic anemia;5-aminolevulinic acid synthase;ALAS E;ALASE;ANH1;Delta aminolevulinate synthase;FLJ93603;OTTMUSP00000020679;XLSA;5 @aminolevulinate synthase erythroid specific;5 aminolevulinic acid synthase 2;5-aminolevulinate synthase 2;5-aminolevulinate synthase;Alas 2;ALAS;ALAS, erythroid;Aminolevulinic acid synthase 2, erythroid;ASB;Delta ALA synthase 2;Delta ALA synthetase;Delta aminolevulinate synthase 2;Erythroid specific ALAS;OTTHUMP00000023388;OTTHUMP00000023389;RP23-338A17.1;XLDPP;OTTHUMP00000204081;delta-ALA synthase 2;delta-ALA synthetase;5-aminolevulinic acid synthase 2;delta-aminolevulinate synthase 2;XLEPP;ALAS-E
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALAS2-27277TH | Recombinant Human ALAS2, His-tagged | E.coli | Human | His | 136-553 a.a. |
|
| ALAS2-419H | Recombinant Human Aminolevulinate, Delta-, Synthase 2, His-tagged | E.coli | Human | His | 136-553 a.a. |
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| ALAS2-430H | Recombinant Human ALAS2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALAS2-431H | Recombinant Human ALAS2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ALAS2-611R | Recombinant Rat ALAS2 Protein | Mammalian Cell | Rat | His |
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| ALAS2-9209Z | Recombinant Zebrafish ALAS2 | Mammalian Cell | Zebrafish | His |
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| ALAS2-55HCL | Recombinant Human ALAS2 cell lysate | Human | Non |
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| ALAS2-112H | Recombinant Human ALAS2 Protein, His-tagged | E.coli | Human | His | Ala361-Ala587 |
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| Alas2-113M | Recombinant Mouse Alas2 Protein, His-tagged | E.coli | Mouse | His | Ala361-Ala587 |
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| ALAS2-1391HF | Recombinant Full Length Human ALAS2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 587 amino acids |
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| ALAS2-2505H | Recombinant Human ALAS2 protein, His-tagged | E.coli | Human | His | 50-587aa |
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| Alas2-2506M | Recombinant Mouse Alas2 protein, His-tagged | E.coli | Mouse | His | 50-587aa |
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| ALAS2-267R | Recombinant Rat ALAS2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ALAS2-267R-B | Recombinant Rat ALAS2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
ALAS2 involved in several pathways and played different roles in them. We selected most pathways ALAS2 participated on our site, such as Glycine, serine and threonine metabolism,Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | UROD,HEPH,GUSB,EPRS,UGT1A9,HCCSB,HMOX2A,UGT1A7,HMBSA,UGT1A1 |
| Glycine, serine and threonine metabolism | GRHPRA,PSPH,GCAT,THA1,PIPOX,GRHPR,MAOA,AGXTB,DLDH,SHMT1 |
| Metabolic pathways | OAT,MAN1C1,IDUA,PGAM1,IDO1,FH,NAMPT,SLC27A5,ATP6V1G3,CKB |
Protein Function
ALAS2 has several biochemical functions, for example, 5-aminolevulinate synthase activity,coenzyme binding,glycine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAS2 itself. We selected most functions ALAS2 had, and list some proteins which have the same functions with ALAS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coenzyme binding | TDH,HMGCRB,ATAT1,HMGCRA,QDPRB1,GCH1,TDH2,GCLC,ACAT1,NDUFA9 |
| protein binding | DYM,CDCA5,CCDC116,SUMO3,OBSCN,HORMAD1,ADAMTS10,MEPE,KAT5,OPRD1 |
| pyridoxal phosphate binding | PYGL,PYGM,PHYKPL,MARC2,MOCOS,CCBL1,CBSA,GAD1B,GPT2,GAD2 |
| glycine binding | GRIN3A,GLDC,SIX2A,GLRA1,GLRA2,GNMT,GLRA4A,GRIN2B,GRIN3B,GRIN1 |
| 5-aminolevulinate synthase activity | ALAS1 |
Interacting Protein
ALAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAS2.
BANP;GRB2
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