AKT2

  • Official Full Name

    v-akt murine thymoma viral oncogene homolog 2
  • Overview

    This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
  • Synonyms

    Akt2;AKT2_HUMAN;PKB;PKB beta;PKBBETA;PRKBBy;Protein kinase Akt 2;Protein kinase Akt-2;Protein kinase B beta;RAC BETA;RAC beta serine threonine protein kinase;RAC PK beta;Rac protein kinase beta;RAC-beta serine/threonine-protein kinase;RAC-PK-beta;RACbeta;V AKT Murine Thymoma Viral Oncogene Homolog 2

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Zebrafish
  • Mouse
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • E.coli
  • HEK293
  • GST
  • His
  • His&GST
  • Flag
  • His&T7
  • Non
  • His&Fc&Avi
  • His&SUMO
  • HIS
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
AKT2-102H Active Recombinant Human AKT2, GST-tagged Sf9 Cells Human GST
AKT2-103H Active Recombinant Human AKT2, GST-tagged Sf9 Cells Human GST
AKT2-1364H Active Recombinant Human AKT2, His-tagged Sf9 Cells Human His Full length
AKT2-163H Active Recombinant Human AKT2, His-tagged Sf9 Cells Human His
AKT2-424H Active Recombinant Human AKT2 Protein, GST-His tagged Insect Cells Human His&GST 107-481 a.a.
AKT2-802H Active Recombinant Human AKT2, GST-tagged Sf9 Cells Human GST
AKT2-260HFL Active Recombinant Full Length Human AKT2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
AKT2-165H Recombinant Human AKT2, His-tagged Insect Cells Human His
AKT2-166H Recombinant Human AKT2, His-tagged Sf9 Cells Human His Full L.
AKT2-1841H Recombinant Human AKT2 protein, His & T7-tagged E.coli Human His&T7 Lys142~Ile412
AKT2-248H Active Recombinant Human AKT2 Protein, His & GST-tagged Insect Cells Human His&GST 1-481 a.a.
AKT2-297R Recombinant Rhesus monkey AKT2 Protein, His-tagged Mammalian Cells Rhesus macaque His
AKT2-31H Recombinant Human AKT2 protein, Flag-tagged, Biotinylated Insect Cells Human Flag 120-481 a.a.
AKT2-606R Recombinant Rat AKT2 Protein Mammalian Cells Rat His
AKT2-9802Z Recombinant Zebrafish AKT2 Mammalian Cells Zebrafish His
AKT2-985H Recombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged Sf9 Cells Human His 142-end a.a.
AKT2-8927HCL Recombinant Human AKT2 293 Cell Lysate HEK293 Human Non
ACSBG2-3422H Recombinant Human ACSBG2 protein, His-tagged E.coli Human His 367-666 aa
ACSF3-7353H Recombinant Human ACSF3 protein, His-tagged E.coli Human His 226-576 aa
AKT2-0082H Recombinant Human AKT2 Protein (N2-E481), Tag Free Insect Cells Human Non N2-E481
AKT2-0083H Recombinant Human AKT2 Protein (N2-E481), GST tagged Insect Cells Human GST N2-E481
AKT2-0351H Recombinant Human AKT2 Protein (Met1-Lys146), N-His-tagged E.coli Human His Met1-Lys146
AKT2-125R Recombinant Rhesus Macaque AKT2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
AKT2-125R-B Recombinant Rhesus Macaque AKT2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
AKT2-2504H Recombinant Human AKT2 protein, His-SUMO-tagged E.coli Human His&SUMO 2-481aa
AKT2-26262TH Recombinant Human AKT2, His-tagged Human HIS 142-481 a.a.
AKT2-262R Recombinant Rat AKT2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
AKT2-262R-B Recombinant Rat AKT2 Protein Pre-coupled Magnetic Beads HEK293 Rat
AKT2-307H Recombinant Human AKT2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
AKT2-307H-B Recombinant Human AKT2 Protein Pre-coupled Magnetic Beads HEK293 Human
Akt2-567M Recombinant Mouse Akt2 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK

    Involved Pathway

    AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway MET,GNG12,ELK1,PRKACG,GNG2,ARF6,NGFR,PIK3R3,RAB5C,REL
    Non-alcoholic fatty liver disease (NAFLD) RAC1,PIK3R1,SOCS3,LEPR,RELA,NDUFV3,COX8C,NDUFS2,PIK3CB,DDIT3
    Rap signaling pathway PLCG1,CALM4,ACTB,PDGFD,FPR1,CALM2,PRKD3,PLCB2,PFN3,ANGPT1
    Fc gamma R-mediated phagocytosis PIK3CA,VASP,WASL,cgr2b,DOCK2,VAV1,PIK3R2,PRKCB,INPPL1,MYO10
    Apoptosis DBNL,TRAF2,VIML,BIRC5A,HELLS,IRF2,ADD1,JUN,BIRC8,DERL3
    Estrogen signaling pathway HRAS,GRB2,CALML5,CREB5,GNAI3,HSP90AA1,GRM1,PLCB4,AKT1,GNAI2
    Jak-STAT signaling pathway PIK3CG,IL22,IL12RB2,IL3RA,IFNA3,IL12A,GM13305,IFNA5,CCND1,IL28RA
    VEGF signaling pathway PIK3R1,PPP3R1,SRC,VEGFA,PTGS2,NRAS,RAF1B,RAC2,VEGFAB,NFATC2
    Dopaminergic synapse CAMK2A,MAPK12,CREB3L3,PRKCA,DRD2,KIF5B,CLOCK,TH,GSK3B,DRD1A

    Protein Function

    AKT2 has several biochemical functions, for example, ATP binding,protein binding,protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STK40,KIF4A,KIF2A,TEC,MVD,PKDCCA,SMARCA4,PINK1,BCR,DAPK3
    protein kinase C binding SQSTM1,TWF2,TRPV4,IRS1,TIRAP,ADD3,PARD3,DACT1,HDAC7A,HINT1
    protein binding DNMT3A,BCL11A,CAMP,CLOCKB,ATRNL1,GAPDHS,AZU1,RFC4,PRRG2,GSDMD
    protein serine/threonine kinase activity SIK2,OBSCN,RPS6KA2,CAMK2D1,ILK,SRPK1A,DCKL1B,STK40,STK32A,PIK3CA

    Interacting Protein

    AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.

    HSP90AB1;crosstide;CASP3;GSK3B;LRRK2;SH3RF1;MYH13;VIM;SETDB1;CDC37;SORBS2;APOA1;APOB

    AKT2 Related Signal Pathway

    Resources

    References

    • van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
    • Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

    Ask a Question for All AKT2 Products

    Required fields are marked with *

    My Review for All AKT2 Products

    Required fields are marked with *