AIMP1

  • Official Full Name

    aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

  • Overview

    The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.

  • Synonyms

    AIMP1;aminoacyl tRNA synthetase complex-interacting multifunctional protein 1;p43;EMAP2;SCYE1;EMAPII;aminoacyl tRNA synthase complex-interacting multifunctional protein 1;OTTHUMP00000161877;OTTHUMP00000161878;OTTHUMP00000219673;ARS-interacting multifunctional protein 1;endothelial monocyte-activating polypeptide 2;multisynthase complex auxiliary component p43;endothelial-monocyte activating polypeptide II;multisynthetase complex auxiliary component p43;small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating);AIMP1/p43;9830137A06Rik

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E. coli
  • Human
  • Human Cell
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • StrepII

    Involved Pathway

    AIMP1 involved in several pathways and played different roles in them. We selected most pathways AIMP1 participated on our site, such as Cytosolic tRNA aminoacylation,Gene Expression,tRNA Aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression TH1L,SLC38A8,LCMT2,ZNF680,PTRFB,ZNF792,ZNF221,RRAGA,ZNF334,ZFP36L1
    tRNA Aminoacylation KARS,MADD,FARS2,WARS2,EEF1E1,FARSB,AARS,AIMP2,EARS2,DARS
    Cytosolic tRNA aminoacylation AARS,EEF1E1,KARS,FARSB,MADD,AIMP2,DARS

    Protein Function

    AIMP1 has several biochemical functions, for example, GTPase binding,cytokine activity,NOT methionine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AIMP1 itself. We selected most functions AIMP1 had, and list some proteins which have the same functions with AIMP1. You can find most of the proteins on our site.

    Function Related Protein
    protein homodimerization activity VIL1,ANXA1,TRIM5,CR2,XCL1,PAFAH1B2,BARD1,PARK7,ERBB3,SYT6
    tRNA binding TRMT1,YARS,IFIT5,EEF1A1,EARS2,SEPSECS,CTU2,MADD,TRMT11,KARS
    GTPase binding SPTBN1,EPRS,RASA1,PTPRN,GOLGA4,RAB3D,ENO1,VPS41,LCP1,YBX1
    NOT methionine-tRNA ligase activity LARS
    protein binding TRIM39,SPAG8,MTA3,TAF3,SPON2,GTF2I,SIM1,HELZ2,TJP1,CCL5
    cytokine activity IL11,SP100,IFNG1-1,FAM3D,C1QTNF4,GREM1A,CMTM2,CMTM7,IL12BA,Ctf2

    Interacting Protein

    AIMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIMP1.

    gag;AIMP2;TSNAX;MCC;HLA-B;ARF6;IKBKE;FTSJ1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;midostaurin;ssrna_ug

    Resources

    Research Area

    Other Cytokines & Receptors
    Inflammatory Mediators

    References

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    Q&As

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