ADM
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Official Full Name
adrenomedullin -
Overview
Adrenomedullin is a peptide associated with pheochromocytoma- a tumour arising from adrenal medulla. It was discovered in 1993. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 1993. Since its first report, studies examining the effects of adrenomedullin have mushroomed, highlighting its role in a number of diseases. Recently a second peptide AM2 has been recognised, exhibiting similar functions. -
Synonyms
ADM;adrenomedullin;AM;preproadrenomedullin
Recombinant Proteins
- Mouse
- Dog
- Human
- Rat
- Cattle
- Chimpanzee
- Mammalian Cell
- E.coli
- E. coli
- E.Coli or Yeast
- Wheat Germ
- HEK293
- Human Cell
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Fc
- Non
- His&Myc
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
ADM involved in several pathways and played different roles in them. We selected most pathways ADM participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | RYK,RBP4,RDH13,ARHGAP17,SOX9B,OXGR1A.1,ARHGAP12B,OPN1LW2,CDC42EP3,ABI1B |
| GPCR downstream signaling | ADCYAP1B,PYY,TAC3,PTHLHA,CRHB,SSTR2,GPR132B,RAMP1,VIP,RXFP2 |
| Calcitonin-like ligand receptors | RAMP1,RAMP3,RAMP2,CALCB,ADM2A,ADM2,CALCA,CALCRL |
| G alpha (s) signalling events | CALCB,POMCB,ADM2,CALCA,PDE10A,RLN2,RXFP2,ADORA2B,PTHLH,CALCRL |
| Class B/2 (Secretin family receptors) | SETD6,CALCRL,SCT,GCGB,RCA2.1,CRHR2,ADCYAP1B,GNB5A,ADCYAP1,EMR3 |
| GPCR ligand binding | OPN1LW,MLN,GHRH,EDNRA,RAMP3,DRD3,FFAR3,LPAR2B,PENKB,QRFP |
| HIF-1-alpha transcription factor network | NDRG1,PLIN2,GATA2,CP,ENG,TFF3,CITED2,EGLN3,NPM1,COPS5 |
| Myometrial Relaxation and Contraction Pathways | RGS6,RGS5,PKIB,RXFP2,RAMP3,MYLK2,IGFBP2,GPR182,CORIN,RGS7 |
Protein Function
ADM has several biochemical functions, for example, adrenomedullin receptor binding,hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADM itself. We selected most functions ADM had, and list some proteins which have the same functions with ADM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | REN,F7,NXPH3,KNG1,CXADR,Itga10&Itgb1,FGF13A,TNFSF13,FASLG,CX3CL1 |
| hormone activity | PRL4A1,CGA,GPHB5,URP2,STC1L,GPHA2,HAMP,LEPA,IGF2B,ADCYAP1A |
| protein binding | MLF2,C7orf25,GABBR2,PLEKHF2,REG3A,FAM129A,KL,C19orf46,NRIP1,PVRL2 |
Interacting Protein
ADM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADM here. Most of them are supplied by our site. Hope this information will be useful for your research of ADM.
Resources
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References
- Gils, A; Vande Casteele, N; et al. Development of a Universal Anti-Adalimumab Antibody Standard for Interlaboratory Harmonization. THERAPEUTIC DRUG MONITORING 36:669-673(2014).
- Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).
