ADI1
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Official Full Name
acireductone dioxygenase 1 -
Overview
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. -
Synonyms
ADI1;acireductone dioxygenase 1;1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase;APL1;ARD;FLJ10913;HMFT1638;membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1;MTCBP 1;SIPL;1;2-dihydroxy-3-keto-5-methylthiopentene dioxygenase;Aci reductone dioxygenase;Acireductone dioxygenase (Ni(2+)-requiring);ADI 1;anti ADI1;EC 1.13.;Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;MTCBP-1;MTCBP1;MTND_HUMAN;Ni-ARD;Submergence induced protein 2 homolog;Submergence-induced protein 2 homolog;submergence induced protein 2;MT1-MMP cytoplasmic tail-binding protein-1;membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ADI1 involved in several pathways and played different roles in them. We selected most pathways ADI1 participated on our site, such as Cysteine and methionine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | MDH1AA,GCLM,BHMT,MAT2AL,LDHBB,LDHAL6A,AHCYL2,MAT2A,SDS,MAT1A |
| Metabolic pathways | SAT2B,GALNT18A,POLR1B,PLA2G2E,POLR3GLB,DAD1,ENO1B,PIP5K1A,PIP5K1B,PGM2 |
Protein Function
ADI1 has several biochemical functions, for example, acireductone dioxygenase [iron(II)-requiring] activity,metal ion binding,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADI1 itself. We selected most functions ADI1 had, and list some proteins which have the same functions with ADI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | GALNT13,ZNF436,ZNF785,CISD1,AARS2,NUDT12,ADIPOR2,ZNF302,WTIP,FYN |
| oxidoreductase activity | CYP2C37,Scd1,TESCA,MOXD2,ADH8B,GPD1,DHRS3A,SDR42E1,AKR1B8,BCO1 |
| protein binding | ZNF133,NOTCH4,PPP2R5D,RFESD,RAD23B,SEC13,CDKN3,GAPDH,HEMK1,SULT1B1 |
Interacting Protein
ADI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADI1.
MMP14;SRPK1;DBT;OSTF1
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References
- Valdez, CE; Smith, QA; et al. Mysteries of Metals in Metalloenzymes. ACCOUNTS OF CHEMICAL RESEARCH 47:3110-3117(2014).
- Allpress, CJ; Berreau, LM; et al. A Nickel-Containing Model System of Acireductone Dioxygenases that Utilizes a C(1)-H Acireductone Substrate. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY :4642-4649(2014).
