ACY1
-
Official Full Name
aminoacylase 1 -
Overview
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. -
Synonyms
ACY1;aminoacylase 1;aminoacylase-1;acylase;N-acyl-L-amino-acid amidohydrolase;ACY-1;ACY1D
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Human Cell
- Insect Cells
- E.coli
- Wheat Germ
- Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- T7
- GST
- Flag
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ACY1 involved in several pathways and played different roles in them. We selected most pathways ACY1 participated on our site, such as Arginine biosynthesis,Metabolic pathways,-Oxocarboxylic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NMRK1,FH1,PLCB3,OXSR1,TST,NDUFA11,GAPDHS,ENO1B,HAAO,ATP6V1G3 |
| Arginine biosynthesis | OTC,NOS1,GLUD1B,NOS2A,NOS2B,NAGS,GOT1,ASL2,GOT2A,GLULC |
| -Oxocarboxylic acid metabolism | GPT,GOT2,ACO1,IDH3B,AADAT,GPT2,BCAT1,BCAT2,IDH1,ACO2 |
| Biosynthesis of amino acids | PKMA,PKLR,MAT2B,TKT,GPT2,ENO1A,GOT1,PSAT1,CS,PYCRL |
Protein Function
ACY1 has several biochemical functions, for example, aminoacylase activity,metal ion binding,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACY1 itself. We selected most functions ACY1 had, and list some proteins which have the same functions with ACY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallopeptidase activity | CNDP2,ADAM1B,HE1B,ADAM30,BMP1A,ADAM23,CPD,ADAMTSL1,YME1L1,MMP14A |
| protein binding | CTGF,RAD50,APOO,STEAP3,FGFR4,UTP3,SDHA,MYO10,ATP2C2,HSPB2 |
| aminoacylase activity | DARS,ASPA,ACY3,CAT |
| metal ion binding | ATP13A3,DGKAA,ADCY7,ADAP1,MAP3K3,EPX,IMPDH1,ZBTB46,POLI,ZNF503 |
Interacting Protein
ACY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACY1.
TERF1;TFAP2A;NPM1;BBS7;BBS4;TTC1;BBS2;POT1;GSTP1
Resources
Related Services
Related Products
References
