ACTR1A
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Official Full Name
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -
Overview
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size;from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of;cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle;formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per;dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is;approximately 60% identical at the amino acid level to conventional actin. -
Synonyms
ACTR1A;ARP1 actin-related protein 1 homolog A, centractin alpha (yeast);ARP1 (actin related protein 1, yeast) homolog A (centractin alpha);alpha-centractin;ARP1;actin related protein 1;Actin RPV;ACTR 1A;Alpha Centractin;ARP 1;ARP1 actin related protein 1 homolog A;ARP1 actin related protein 1 homolog A centractin alpha;ARP1 yeast homolog A;Centractin alpha;Centractin;Centrosome associated actin homolog;CTRN 1;CTRN1;FLJ52695;FLJ52800;FLJ55002;actin-RPV;centrosome-associated actin homolog
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Human
- Cynomolgus
- Rat
- Mammalian Cell
- Wheat Germ
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ACTR1A involved in several pathways and played different roles in them. We selected most pathways ACTR1A participated on our site, such as Adaptive Immune System,Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | CENPJ,MKS1,CKAP5,MARK4,DYNC1H1,TUBB4A,FGFR1OP,CCDC123,MAPRE1,TUBB4B |
| Immune System | DEFB4B,CLEC2D,NOD1,NPEPPS,IRF2,EGR1,TRIM38,TRIM3,CTSH,MB21D1 |
| G2/M Transition | CEP78,CCP110,CDK11A,CEP152,ODF2B,TUBGCP4,NUMA1,CEP135,TUBGCP5,MYBL2 |
| Assembly of the primary cilium | DCTN3,CP110,TRAF3IP1,IFT52,IFT88,TSGA14,TCTEX1D2,KIF3A,IFT27,EXOC3 |
| Cell Cycle, Mitotic | KNTC1,CEP72,NDEL1,E2F4,ERCC6L,SGOL2,NCAPD3,NEK6,ITGB3BP,TOP2A |
| Adaptive Immune System | AMICA1,CD300LB,FBXO17,KIF3A,KLRG1,SPSB4,VPRBP,NRG2A,ASB6,AP1M2 |
| Cell cycle | NDEL1A,CLASP1,TGFB1A,NCAPH,TTK,HAUS2,DKC1,STAG2A,GADD45A,GINS4 |
| Centrosome maturation | CSNK1E,CEP57,PLK4,NUMA1,PCM1,CEP76,MAPRE1,FGFR1OP,DCTN1A,TUBGCP3 |
Protein Function
ACTR1A has several biochemical functions, for example, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTR1A itself. We selected most functions ACTR1A had, and list some proteins which have the same functions with ACTR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KATNA1,TUT1,KIF6,MARK1,ORC1L,CMPK2,YRK,MARK2,DHX36,SARS2 |
Interacting Protein
ACTR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTR1A.
Dctn1;Dctn2;Dctn3;HLA-B;Capza1;Actr1a;Cep76;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ZFC3H1;PTBP3;CAPZA2;Dynlrb1;Nfyc;Cct2;Cct4;Prkcz;SNW1
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