ABCB1
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Official Full Name
ATP-bindingcassette, sub-family B (MDR/TAP), member 1 -
Overview
P-glycoprotein (permeability glycoprotein, abbreviated as P-gp or Pgp) is a well-characterized ABC-transporter of the MDR/TAP subfamily. P-gp is also called ABCB1, ATP-binding cassette sub-family B member 1, MDR1, and PGY1. P-glycoprotein has also recently been designated CD243 (cluster of differentiation 243). In humans, P-glycoprotein is encoded by the ABCB1 gene. Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier. Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. -
Synonyms
ABC20;ABCB1;ATP binding cassette sub family B MDR/TAP member 1;ATP-binding cassette sub-family B member 1;CD243;CD243 antigen;CLCS;GP170;MDR1;Multidrug resistance protein 1;P glycoprotein 1;P gp;P-glycoprotein 1;PGY1 antibody;P-Glycoprotein;ABCB1;ATP-bindingcassette, sub-family B (MDR/TAP), member 1
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Mouse
- E.coli
- Wheat Germ
- Insect Cells
- Mammalian Cells
- Human Cells
- HEK293
- GST
- His
- His&GST
- Flag
- His&Fc&Avi
Involved Pathway
ABCB1 involved in several pathways and played different roles in them. We selected most pathways ABCB1 participated on our site, such as ABC transporters,Bile secretion,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | ATP1B3,SLCO1A2,SLC9A3,EPHX1,SCARB1,GNAS,KCNN2,SLC51B,Abcb1b,ATP1A1 |
| ABC transporters | TAP1,ABCC2,ABCC10,ABCA7,ABCC1,ABCB6A,CFTR,ABCG3,ABCA1B,ABCB4 |
| MicroRNAs in cancer | NOTCH4,PRKCA,ZFPM2,NFKB1,BAK1,GLS2,MAP2K1,CYP24A1,TPM1,ROCK1 |
Protein Function
ABCB1 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB1 itself. We selected most functions ABCB1 had, and list some proteins which have the same functions with ABCB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STK24,RFC3,ACKR4,GPR77,NOL12,TBC1D9B,DERL2,TAGLN,RAB33A,CDKN2A |
| ATP binding | UBE2D4,NAIP6,DHX38,THRAP3,CSF1R,ACVR1C,IRAK3,EPRS,MTPAP,DARS |
| xenobiotic-transporting ATPase activity | ABCB4,ABCG2,ABCB1A,Abcb1b |
| transporter activity | ABCA9,SLC6A20B,RBP7,RBP2A,TCIRG1,NUP98,SYPL2B,AP2S1,FABP1A,SLC37A4B |
| ATPase activity, coupled to transmembrane movement of substances | IPO8,SFRP5,DPY19L2,ABCA6,ABCD1,ABCB1A,ABCC5,ABCA4,ABCC2,TAP1 |
Interacting Protein
ABCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB1.
RNF2;LAPTM4B;PHB2;CD4;MAPKAP1;BCCIP;MYC;CAV1;LAPTM4B
Resources
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References
- Pozniak, B; Pawlak, A; et al. Flow Cytometric Assessment of P-glycoprotein and Multidrug Resistance-associated Protein Activity and Expression in Canine Lymphoma. IN VIVO 29:149-153(2015).
- Teunissen, MBM; Yeremenko, NG; et al. The IL-17A-Producing CD8(+) T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:2898-2907(2014).
